多因素所致温病湿热证模型大鼠红细胞免疫功能的变化  

The effect of multiple factors on erythrocytoimmunity function in dampness heat model rats of epidemic febrile disease

作　　者：佟丽[1] 陈江华[1] 吴仕九[1] 杨运高[1] 杨钦河[1] 刘立[1] 

机构地区：[1]第一军医大学中医系

出　　处：《中国免疫学杂志》1999年第8期366-368,共3页Chinese Journal of Immunology

基　　金：广东省科委自然科学基金

摘　　要：目的：探讨高温、高湿环境，同时给予高脂、高糖饲料，并感染不同的病原微生物等因素对大鼠红细胞免疫功能的影响。方法：采用红细胞酵母菌混合花环法测定大鼠红细胞Ｃ３ｂ受体花环数（ＥＣ３ｂＲＲ）和红细胞免疫粘附物（ＥＩＣＲ）花环数。结果：在多因素作用下，模型大鼠外周血中红细胞Ｃ３ｂ受体花环数（ＥＣ３ｂＲＲ）显著降低，而红细胞免疫粘附物（ＥＩＣＲ）升高。除去病原微生物作用，大鼠在高脂高糖、高温高湿环境，ＥＣ３ｂＲＲ显著降低和ＥＩＣＲ水平均显著降低；将动物给予普通饲料，置于高温高湿环境，ＥＣ３ｂＲＲ显著降低，而ＥＩＣＲ水平无显著变化。Objective:To probe into effect several factors such as high temperature, high humidity, high sugar and high fat diet and infection of pathogenic microorganisms on erythrocytoimmunity function in rats model of dampness heat. Methods:The number of blood erythrocyte C 3b receptor rosettes and immune complex rosettes (E ICR) in the rats model were tested by red cell and yeast mixture rose. Results:Blood erythrocyte C 3b receptor rosette (E C 3b R) of rats decrased but erythrocyte immune complex rosette (E ICR) increased significantly to induce by multiply factors. Both of E C 3b R and E ICR were decreased significantly induced by high temperature, high humidity and high sugar and fat diet.Except the pathogenic microorganisms. In high temperature and humidity, E C 3b R of the experimental rat which fed by common diet decreased significantly but the level of E ICR had not any change. Conclusion:Erythrocytoimmunity function of dampness heat rats of epidemic febrile disease changed significantly when multiple factors affected it together.

关 键 词：红细胞C3B受体 湿热证 动物模型 温病 

分 类 号：R254.203[医药卫生—中医内科学]