正交试验法优选健肾片的提取工艺  

Study on Extraction Process for Jianshen Tablet by Orthogonal Test

作　　者：郭传宝[1] 曹光环[1] 邵杰[1] 尚强[1] 徐连明[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001

出　　处：《中国实验方剂学杂志》2011年第11期13-16,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制--创新中药中试放大研究技术平台(2009ZX09313-032)

摘　　要：目的:优选健肾片的提取工艺。方法:考察黄芪的形状对黄芪甲苷提取率的影响,并采用正交试验法,以提取液中黄芪甲苷、淫羊藿苷的得率和干膏率为考察指标,考察加水量、提取时间和提取次数3个因素对提取结果的影响。结果:最佳提取工艺为加8倍量水提取2次,每次1.5 h,黄芪药材炮制的形状为段长(5～10 mm)。结论:该工艺合理可行,含量测定方法稳定可靠。Objective：To optimize the extraction technology for Jianshen tablet.Method：The shape of Radix Astragalus was studied on the content of astragaloside Ⅳ and orthogonal test was used for studying the effect of water volume,extraction time and times on the content of icariin,astragaloside Ⅳ and solid.Result：The optimal extraction process was as follows：with 8 times of water extracted twice,each time for 1.5 h.The processing method of Radix Astragali was cutting for about 5-10 mm.Conclusion：The extraction process is reasonable and feasible.The method of content determination is accurate and reliable.

关 键 词：健肾片 提取工艺 正交试验 淫羊藿苷 黄芪甲苷 

分 类 号：R283.6[医药卫生—中药学]