蝙蝠葛果提取物抗大鼠实验性心律失常和降压作用研究  

Anti-arrhythmia and Anti-hypertensive Effects of Extract from Menispermum dahuricum in Rats

作　　者：许贞爱[1] 张红英[2] 杨恩月[1] 张宝莲[1] 

机构地区：[1]延边大学附属医院,吉林延吉133000 [2]延边大学基础医学院机能学实验中心,吉林延吉133002

出　　处：《中国实验方剂学杂志》2011年第11期189-191,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究蝙蝠葛果提取物(MD)对药物诱发大鼠实验性心律失常和降血压的作用。方法:制备乌头碱、氯化钡(BaCl2)诱发的大鼠实验性心律失常模型,常规测定血压。记录给乌头碱后出现的室早(VA)、室速(VT)、室颤(VF)时的乌头碱用量;记录给BaCl2后心律失常出现时间和维持时间;记录给蝙蝠葛果提取物自身前后血压的变化。结果:MD(40 mg·kg-1 i,v)可明显提高乌头碱诱发大鼠出现室早、室速时的乌头碱用量;MD(40,20 mg·kg-1 i,v)可明显提高大鼠出现室颤时乌头碱用量,可明显推迟氯化钡诱发大鼠心律失常出现时间和缩短维持时间;MD(40 mg·kg-1)降压效果明显,降压持续时间明显延长。结论:MD对2种药物诱发的实验性心律失常均具有明显保护作用,MD有一定降压作用且降压效果明显持久。其抗心律失常机制可能与抑制钙离子、钠离子跨膜流动有关。Objective：To study the experimental anti-arrhythmia and anti-hypertensive effects of extract from Menispermum dahuricum（MD）.Method：The experimental arrhythmia model in rat was caused by aconitine and BaCl2.The blood pressure was measured.The occurrence of VA,VT,VF caused by aconitine in rats was recorded,and arrhythmias caused by BaCl2 in rats was recorded.Blood pressure was monitored in rats before and after the treatment of extract from MD.Result：MD（40 mg·kg-1,iv） could significantly increase the amount of aconitine for inducing VP and VT in rats;MD（40,20 mg·kg-1,iv） could increase amounts of aconitine for inducing VF in rats.MD（40,20 mg·kg-1,iv） could delay the occurrence of arrhythmia induced by BaCl2 and shorten the duration of arrhythmia in rats.MD（40 mg·kg-1） showed obvious anti-hypertensive effect,the anti-hypertensive duration was lasted significantly.Conclusion：MD has significant protective effect to the experimental arrhythmia induced by drugs.MD has lasting anti-hypertensive effect.The anti-arrhythmic mechanism is likely related to inhibition of transmembrane movement of Ca2＋ and Na＋.

关 键 词：蝙蝠葛果提取物 乌头碱 氯化钡 心律失常 血压 

分 类 号：R285.5[医药卫生—中药学]