2-杂环基-1,3,4-二嗪酮类化合物的合成及其除草活性  

Synthesis and herbicidal activity of 2-heterocyclic 1,3,4-oxadiazine-5-ones

作　　者：潘玲玲[1] 沈晓霞[2] 曹瑾[2] 陈亮[2] 沈宙[2] 袁莉萍[2] 张一宾[2] 

机构地区：[1]华东理工大学药学院,上海200237 [2]上海市农药研究所,上海200032

出　　处：《农药学学报》2011年第3期239-244,共6页Chinese Journal of Pesticide Science

基　　金："十一五"国家科技支撑计划项目(2006BAE01A01-6)

摘　　要：以取代杂环羧酸为起始原料,在1,3,4-二嗪-5-酮的2-位上分别引入呋喃环、吡啶环及氯代噻吩环,合成了31个未见报道的2-杂环基-1,3,4-二嗪酮化合物,其化学结构经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,该类化合物具有良好的除草活性,如在质量浓度200 mg/L时,化合物E14、E16、E20、E21对马唐Digitaria sanguinalis的抑制率大于90%,化合物E06、E07、E10、E14、E16、E20对苋菜Ambrosia tricolor的抑制率也大于90%。Thirty one novel compounds of 2-heterocyclic-1,3,4-oxadiazine-5-one derivatives were synthesized through the starting material substituted heterocyclic carboxylic acid.The structure of all compounds was confirmed by 1H NMR and elemental analysis.The preliminary assays showed that some compounds exhibited significant herbicidal activity.The inhibition rate of E14,E16,E20 and E21 to the Digitaria sanguinalis and E06,E07,E10,E14,E16 and E20 to the Ambrosia tricolor reached 90% at the mass concentration of 200 mg/L.

关 键 词：1 3 4-二嗪-5-酮 有机合成 除草活性 

分 类 号：O626.4[理学—有机化学]