表阿霉素聚氰基丙烯酸正丁酯磁性纳米粒的制备与表征  

Preparation and characterization of epirubicin polybutylcyanoacrylate magnetic nanoparticles

作　　者：李坚[1] 赵劲风[2] 潘一峰[2] 段菁华[2] 

机构地区：[1]中南大学湘雅医院肝胆肠外科,长沙410008 [2]卫生部纳米生物技术重点实验室

出　　处：《中华实验外科杂志》2011年第6期911-913,共3页Chinese Journal of Experimental Surgery

基　　金：基金项目：国家十一五“863”计划资助项目（2007AA021810）

摘　　要：目的制备表阿霉素聚氰基丙烯酸正丁酯磁性纳米粒（EPI—PBCA—MNPs）并进行表征。方法以化学共沉淀法制得粒径（15．2±4．6）nm的Fe3O4纳米磁流体，采用微乳液反相界面聚合法制得EPI-PBCA-MNPs，反应条件：pH=2．0，搅拌速度2000r／min，然后对其进行相关表征。结果EPI-PBCA-MNPS粒径为（152．0±28．5）nm，分布均匀，胶体溶液长期稳定，平均包封率为（81．30±15．20）％，平均载药量为（14．65±2．05）％，饱和磁化强度为：0．35KA／m。结论制备的EPI-PBCA-MNPs粒径合适，分布均匀，其主要指标符合肝癌靶向治疗的要求。Objective To prepare and characterize epirubicin polybutylcyanoacrylate magnetic nanoparticles （EPI-PBCA-MNPs） for the purpose of offering a new dosage form of high-performance for targeted therapy of hepatoma. Methods Nanosized Fe3 04 magnetic fluids with the mean particle diameter of （15.2 ±4. 6） nm were prepared by chemical coprecipitation method. Subsequently, EPI-PBCA-MNPs was prepared by a reversed-phase micro-emulsion polymerization method, of which reactive condition was pH = 2. 0 and agitating velocity = 2000 r/min, and was correlatively characterized. Results EPI-PBCA- MNPs were uniformly and stably distributed in the colloid solution with the mean particle diameter of （152. 0 ± 28.5） ran. The mean envelopment rate, drug-loading, saturated magnetization intensity is （81.30 ± 15.20） %, （ 14. 65 ±2. 05） % ,0. 35 KA/m,respectively. Conclusion In this experiment, EPI-PBCA-MNPs is uniformly distributed with satisfactory particle diameter, of which main indexes meet the demand of targeted therapy for hepatoma, offering a new dosage form with applicable potential for anticancer drugs exploration.

关 键 词：表阿霉素 聚氰基丙烯酸正丁酯 磁性纳米粒 

分 类 号：R943[医药卫生—药剂学]