抗癫痫药物对血清叶酸水平的影响  

Effects of Antiepileptic Drugs on the Serum Levels of Folate

作　　者：李 平[1] 吕冰清[1] 杨晓苏[1] 

机构地区：[1]湖南医科大学附属湘雅医院,长沙410008

出　　处：《湖南医学》1999年第4期245-247,共3页Hunan Medical Journal

摘　　要：【目的】探讨抗癫痫药物对癫痫患 者血清叶酸水平的影响。【方法】测定了８３ 名使用单一药物治疗的癫痫患者和４ ４ 名癫痫对照者及３５ 名健康对照者的血清叶酸浓度。另对２５ 名癫痫患者 作服 药 前后 的自 身 对照 观 察。【结果】单 独服用 卡马西 平和 苯妥 因钠 的癫痫 患者，其叶酸 浓度较服药前明显下降，前 后比较差异有显著性（ 均 Ｐ ＜ ０ ．０１） ；而服用丙戊酸者则服药前后叶酸浓度无明显变化（ Ｐ ＞ ０ ．０ ５） 。【结论】卡马西平、苯妥因钠可降低癫痫患者的血清叶酸水平，而丙戊酸无此效应。Objective To observe the effects of antiepileptic drugs(AEDs) on serum falic acid (SF) levels in epileptic patients. Methods There were totally 4 groups tested:①83 epipleptic patients,taking single AEDs;②Epileptic control group—44 epileptic patients who have never taken AEDs;③Normal control group—35 healthy subjects;④Self control group—25 other epileptic patients.SF levels of ①～③ groups were determined,whereas those of group ④ before and after taking AEDs were compared. Results In epileptic patients taking single carbamazepine (CBZ) and phenytoin(PHT),their SF levels were significantly lower than those before drug administration (P<0.01);but no distinct change of SF levels was observed in patients before and after valproic acid (VPA) administration (P>0.05). Conclusions CBZ and PHT decreased signifacantly SF levels of epileptic patients,while VPA had no such an effect.

关 键 词：癫痫 抗惊厥药 叶酸 卡马西平 苯妥因 丙戊酸 

分 类 号：R971.6[医药卫生—药品]