聚合物载药微珠的制备研究  

Study on preparation of drug-loaded polymer beads

作　　者：张艳红[1,2] 王清文[1] 师路[2] 李泽文[2] 张贞浴[2] 孙立国[2] 孙志忠[2] 

机构地区：[1]东北林业大学生物质材料科学与技术教育部重点实验室,哈尔滨150040 [2]黑龙江大学化学化工与材料学院,哈尔滨150080

出　　处：《黑龙江大学自然科学学报》2011年第3期365-368,共4页Journal of Natural Science of Heilongjiang University

基　　金：黑龙江省教育厅科学技术面上项目(11531287)

摘　　要：利用微流控技术制备出粒径大小可控、粒径均匀、形状规则的聚乳酸(PLA)载药微珠,确定了流动相和分散相的条件,研究了分散相与流动相的流速对载药液滴直径的影响及载药量对微珠粒径的影响。结果表明:以聚乙烯醇水溶液为流动相的最佳溶液浓度为8%,分散相中PLA的苯溶液与PLA的1,2-二氯乙烷溶液的体积比为17∶10时密度正合适;分散相的流速越大,微珠粒径越大;流动相的流速越大,微珠粒径越小;载药微珠的尺寸随着载药量的增加而增大。Drug-loaded polylactide（PLA） beads with controlled diameter,uniform size and regular shape were prepared by microfluidic technology,the conditions of the mobile phase and the dispersed phase were determined,effects of the speed of the mobile phase and the dispersed phase on the diameter of drug-loaded drops were investigated,the changes of the beads＇ size with drug loadings were also studied.The results showed that the best concentration of polyvinyl alcohol aqueous solution as the mobile phase was 8%.The density was appropriate when the volume ratio of benzene solution of PLA and 1,2-dichloroethane solution of PLA was 17 ∶ 10.The size of drug-loaded beads was increased with the increase of drug loading and the flow rate of the dispersed phase,but it was decreased with the increase of the flow rate of the mobile phase.

关 键 词：酮康唑 微珠 聚乳酸 微流控制 

分 类 号：TP23[自动化与计算机技术—检测技术与自动化装置]