莽草酸对大鼠大脑中动脉血栓所致局部脑缺血性损伤的拮抗作用<英文>  

Antagonistic effects of shikimic acid against focal cerebral ischemia injury in rats subjected to middle cerebral artery thrombosis

作　　者：马怡[1] 徐秋萍[1] 孙建宁[1] 白丽敏[1] 郭亚健[1] 牛建昭[1] 

机构地区：[1]北京中医药大学药理教研室

出　　处：《中国药理学报》1999年第8期696-700,共5页Acta Pharmacologica Sinica

基　　金：Project supported by Johnson & Johnson Ltd.

摘　　要：目的:研究莽草酸(SA)对大脑中动脉血栓所致局部脑缺血的影响。方法:用三氯化铁局部涂抹损伤血管形成的大鼠大脑中动脉血栓模型(MCAT)观察SA对行为障碍程度、脑梗塞范围、脑水肿和缺血区脑血流的影响。结果:SA 25、50mg·kg^(-1) ip于MCAT前连续给药3d可分别减小脑梗塞范围51％、42％,使脑含水量由80.7％降致79.8％、79.9％,并可改善行为障碍程度和缺血区脑血流量的降低,病理检查显示,SA 25mg·kg^(-1)组动物MCA内血栓形成极少,脑组织缺血病变较轻。结论:SA可减轻大脑中动脉血栓所致局部脑缺血性损伤。AIM: To study the effects of shikimic acid (SA) on focal cerebral ischemic injury after middle cerebral artery thrombosis (MCAT). METHODS: Thrombosis was induced by FeCl3 in middle cerebral artery of rats. The influences of SA on neurologic deficit (ND), infarct size (IS), brain edema, and cerebral blood flow (CBF) in ischemic region were observed. RESULTS: SA 25 and 50 mg·kg-1 ip for 3 d before MCAT attenuated ND, and reduced IS by 51 % and 42 % ; and decreased brain water content from 80.7 % to 79.8 % and 79.9 %; and increased CBF after ischemia from 50.2 % of the preischemic level to 75.5 % and 73.3 % , respectively. In pathologic examination, there was much less thrombosis in MCA in the rat with the pretreatment by SA 25 mg·kg-1. The extent of brain ischemia was much less than that of control. CONCLUSIONS: SA reduced focal cerebral ischemic injury induced by middle cerebral artery thrombosis.

关 键 词：莽草酸 脑动脉 血栓形成 脑缺血 拮抗作用 

分 类 号：R971.9[医药卫生—药品] R743.303[医药卫生—药学]