局部注射脱钙狗骨粉对兔实验性骨折愈合的促进作用  

AN EXPERIMENTAL STUDY ON THE INFLUENCE OF LOCAL INJECTION OF DECALCIFIED DOG BONE POWDER ON EXPERIMENTAL RABBIT FRACTURE HEALING

作　　者：罗毅文[1] 孙之镐[1] 段戡[1] 朱副平[1] 孙鸿喜[2] 

机构地区：[1]湖南中医学院第一附属医院,长沙410007 [2]湖南中医学院组织形态学教研室

出　　处：《中医正骨》1999年第8期7-8,共2页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：湖南省科委资助项目

摘　　要：采用２４ 只雄性新西兰大白兔，手术造成双侧桡骨中段３ ｍ ｍ 缺损的骨折模型。左侧断端注射脱钙狗骨粉，右侧注射生理盐水作为对照，于治疗后第２ 、４ 、６ 周分３ 批处死，取标本进行 Ｘ 线摄片评分，组织学观察及形态计量学研究，结果显示，实验组 Ｘ 线片评分明显高于对照组（ Ｐ＜ ０ ．０５） ；实验组断端血肿机化快，软骨骨痂出现早，骨化提前，早期形成大量新的小梁骨，血管形成丰富，细胞活性增强，不同时期骨痂中纤维组织，软骨组织，骨小梁变化与对照组相比均有意义。提示局部注射脱钙狗骨粉具有增强骨缺损的修复能力，加速骨折愈合的作用。Animal models of fracture and 3 mm defect were surgically made in the bilateral middle radii of 24 male New Zealand white rabiits. Decalcified dog bone powder was locally injected into the left side fractured site as the experimental group and normal saline into the right side one as the control. The animals were killed in three batches 2, 4, and 6 weeks after the treatment, respectively. The samples were harvested, scored according to the X rays and studied through histological observation and morphometry. The results showed that in the experimental group, the samples obtained higher X ray scores than the control (P < 0.05), the fractured site hematoma was organized more rapidly, the cartilaginous callus and the ossification appeared earlier, a host of new trabecular bone and abundant blood vessels were formed, the cell activity strengthened, and the varied staged changes of fibrous and cartilaginous tissues and bone trabeculae in the callus were significantly different from the control, suggesting that the local injection of decalcified dog bone powder has the function of strengthening the repair ability of bone defect, and speeding up fracture healing.

关 键 词：骨折 治疗 局部注射 脱钙狗骨粉 骨折愈合 

分 类 号：R683.05[医药卫生—骨科学]