胆道支架材料生物相容性的研究  

Investigation on biocompatibility of biliary stent materials

作　　者：刘恒全[1] 黄楠[1] 冷永祥[1] 骆乐[2] 于海亮[3] 李可洲[4] 

机构地区：[1]西南交通大学材料科学与工程学院材料先进技术教育部重点实验室,四川成都610031 [2]泸州医学院临床医学院,四川泸州646000 [3]成都市金牛区人民医院,四川成都610036 [4]成都军区总医院,四川成都610083

出　　处：《功能材料》2011年第6期1068-1070,1074,共4页Journal of Functional Materials

基　　金：国家重点基础研究发展计划(973计划)资助项目(2005CB623904);国家自然科学基金资助项目(50203011;30670565)

摘　　要：胆道支架不仅要求具备优异的力学性能,更重要的是材料在胆道环境中具有良好的生物相容性。采用非平衡磁控溅射设备在不锈钢基体上制备了Ti-O薄膜,研究了其结构及与病人胆汁相互作用。结果表明,Ti-O膜表面具有较高的表面能,不利于细菌粘附及生物膜形成,胆汁稳定性和胆红素变化也是影响支架材料相容性的主要原因,这对开发新型胆道支架材料提供了研究依据。The newly developed biliary stent should have good mechanical properties,as well as excellent biocompatibility in order to meet the needs of reducing immunological reaction in vivo.In this work,Ti-O film was deposited on 316L stainless steel（316L SS） by unbalanced magnetron sputtering device,and the structure of Ti-O film was characterized by X-ray diffraction（XRD）.The interaction of Ti-O film and bile was also investigated by incubating in human fresh bile.The results showed that the surface of Ti-O film could reduce bacteria adherence and form bacterial biofilm owing to more surface energy.The mesobilirubin reducing and the change of the stability of bile are other factors of evaluating biocompatibility.It＇s important to develop new biliary stent materials based on its biocompatibility.

关 键 词：胆道支架材料 生物相容性 Ti-O薄膜 细菌生物膜 

分 类 号：TG174.44[金属学及工艺—金属表面处理] TG113.23[金属学及工艺—金属学]