注射成型羟基磷灰石/聚酰胺6多孔支架的微观结构和力学性能  

Microstructure and mechanical properties of injection molded hydroxyapatite/polyamide-6 porous scaffolds

作　　者：周松[1,2] 李玉宝[1] 王妍媖[1] 左奕[1] 黄棣[1] 张利[1] 

机构地区：[1]四川大学分析测试中心纳米生物材料研究中心,四川成都610064 [2]西南石油大学材料科学与工程学院,四川成都610500

出　　处：《功能材料》2011年第6期1090-1093,共4页Journal of Functional Materials

基　　金：国家高技术研究发展计划(863计划)资助项目(2007AA03Z328766);国家重点基础研究发展计划(973计划)资助项目(2007CB936102)

摘　　要：采用注射成型法制备了羟基磷灰石/聚酰胺6(HA/PA6)多孔支架,用SEM、XRD、DSC等手段表征了支架的组成结构和形貌,检测了其力学性能。研究表明,调节羟基磷灰石(HA)含量、偶氮二甲酰胺(AC)用量和预塑量能有效控制支架的力学性能、孔径大小和孔隙率。HA/PA6支架的孔径在100～500μm左右,孔隙率达到甚至超过65%,压缩模量和压缩强度达到或超过人体骨小梁,并接近人体松质骨的压缩性能,基本能够同时满足支架对力学性能和孔结构的要求。与多孔支架的常规制备方法比较,提供了一种快速便利的制备多孔支架的技术方法。Hydroxyapatite/polyamide-6（HA/PA6） composite scaffolds were prepared using injection-molding technique,and analyzed by SEM,XRD,DSC and mechanical testing.The results demonstrate that this process can effectively control the mechanical properties,porosity and pore size of HA/PA6 composite scaffolds by changing the HA content,the content of azodicarbonamide（AC） and shot size.The HA/PA6 scaffolds with a pore size ranging from 100-500μm and a porosity more than 65% can possess both the demanded porous structure and mechanical performance,and the compressive modulus and strength of the HA/PA6 scaffolds are similar to or higher than those of trabecular bone and close to those of the cancellous bone.Compared with common methods to fabricate scaffolds,this process makes the fabrication of composite scaffolds in a rapid and convenient manner.

关 键 词：多孔支架 聚酰胺6 羟基磷灰石 注射成型 

分 类 号：TB332[一般工业技术—材料科学与工程] TQ320.66[化学工程—合成树脂塑料工业]