慢性肝炎肝硬化患者中医证型与血清肝纤维化指标的关系  

Relationship Between the Serum Indices of Liver Fibrosis and TCM Syndromes Types in Liver Cirrhosis due to Chronic Hepatitis

作　　者：潘志恒[1] 陈琰碧[1] 邓子德[1] 王拥择 关卫兵[1] 杨跃武[1] 

机构地区：[1]中山医科大学附属第三医院,广东省广州市石牌岗顶510630

出　　处：《中医杂志》1999年第8期494-495,共2页Journal of Traditional Chinese Medicine

摘　　要：测定160例慢性肝炎肝硬化患者的血清肝纤维化标志物透明质酸(HA)、Ⅲ型前胶原(hPCⅢ)和Ⅳ型胶原(Ⅳ—C)3项,以探讨中医证型与上述指标的关系。结果显示,各中医证型组的肝纤3项指标均较对照组升高,但改变有各自的特点,其中肝郁脾虚组的平均升高幅度最小。同时发现,湿热中阻组肝纤3项均有显著性升高,肝肾阴虚和瘀血阻络组以HA、hPCⅢ升高为主,脾肾阳虚组以HA、Ⅳ—C升高为主。提示测定上述指标对慢性肝病患者的中医分型有一定指导意义,湿热留恋可能是肝纤维化的启动因素,而血瘀则贯穿于肝纤维化的整个过程。In order to probe into the relationship between the TCM syndrome types and the five indices of fibrotic markers of liver in serum, the HA, hPC I , IV - C in 160 of liver cirrhosis patients induced by chronic hepatitis were examined. Results showed that the 5 indices in all TCM syndrome types were all higher than the control group, each with its specificity. The increased amplitude in the group of liver - stagnant, spleen - deficiency was the least one. It was also found that the 3 indices of liver fibrosis in the group of internal blockade of damp - heat were markedly increased; it was mainly the increase of HA, hPC I in the group of yin-deficiency of both liver - kidney and obstruction of collaterals by static blood; but it was mainly the increase of HA, W - C in the group of Yang - deficiency of spleen and kidney. This demonstrated that the above indices were of significance in TCM syndrome typing for chronic hepatic victims. Lingering of damp -heat may be the trigger factor for liver fibrosis in which blood stasis was present during the whole course of liver fibrosis.

关 键 词：肝硬化 血液 肝 病理学 辨证分型 

分 类 号：R259.752[医药卫生—中西医结合]