复方草珊瑚含片物质组释放特征的研究  

Studies on the Materiomic Release Kinetic Profiles of Compound Caoshanhu buccal tablets

作　　者：楼云雁 石婷婷[2,3] 陈立兵[2] 葛卫红[2] 

机构地区：[1]杭州市第四人民医院,浙江杭州310053 [2]浙江中医药大学,浙江杭州310053 [3]杭州市第三人民医院,浙江杭州310009

出　　处：《中华中医药学刊》2011年第6期1287-1289,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家"十一五"科技支撑计划资助项目(206BAI09B08-08)

摘　　要：目的:考察不同厂家复方草珊瑚含片的物质组释放特性,探讨HPLC检测方法在以多组分整体为评价对象的复方草珊瑚含片的外释放特征研究的可行性。方法:以HPLC为检测手段,超纯水为释放介质,在(37±0.5)℃温度下,采用浆法75 r/m in考察不同批号复方草珊瑚含片的物质组释放特征。结果:20m in时I厂生产的批号为09100023,09100024,09080023的复方草珊瑚含片物质组的平均累积释放百分率分别为89.53%,91.86%,69.51%;释放曲线的W e ibu ll分布参数T50分别为(5.42±0.52)、(7.40±1.07)、(10.85±2.00)m in,Td分别为(7.80±0.54)、(9.99±1.67)、(15.45±2.99)m in。结论:HPLC检测方法适用于以多组分整体为评价对象的复方草珊瑚含片的物质组释放特征研究。Objective： To investigate materiomic release kinetic profiles of Compound Caoshanhu buccal tablets,which detected by HPLC.Moreover,to study the applicability and characteristics of HPLC on the research of Materiomic Release Kinetics of TCMs.Methods： To investigate the discrepancies in materiomic release kinetic profiles of Compound Caoshanhu buccal tablets of different batches produced by the same manufacturer by HPLC detection with the paddle method,water as release medium,75 r·min-1 rotation speeds,the temperature at（37 ± 0.5）℃.Results： The relative materiomic accumulative release percentage of compound Caoshanhu buccal tablets which manufactured by factory I with batch codes as 09100023,09100024,09080023 were 89.53%,91.86% and 69.51% respectively,which released within 20 minutes.The average T50 of Weibull Distribution of the materiomic release profiles were（5.42±0.52）,（7.40±1.07）and（10.85±2.00）min respectively,and the average values of Td were（7.80±0.54）,（9.99±1.67）and（15.45±2.99） min respectively.Conclusion： The HPLC detection methods of materiomic release kinetics of TCM apply to the study of materiomic release of Compound Caoshanhu buccal tablets..

关 键 词：复方草珊瑚含片 中药物质组 中药物质组释放动力学 

分 类 号：R285.5[医药卫生—中药学]