生殖道解脲支原体感染与胚胎停育和反复自然流产关联的meta分析  

A meta-analysis of ureaplasma urealyticum infection of reproductive tract in women with early pregnant failure and recurrent spontaneous abortion

作　　者：裴丽君[1] 王亚菲[1] 刘向国[1] 陈华[1] 卜雯婷[1] 王佳[1] 刘亚芳[1] 郑晓瑛[1] 

机构地区：[1]北京大学人口研究所/WHO生殖健康与人口科学合作中心,100871

出　　处：《中国计划生育学杂志》2011年第6期328-333,共6页Chinese Journal of Family Planning

基　　金：国家重点基础研究发展规划973项目(2007CB511901)资助;2010年教育部人文社会科学规划项目基金(10YJA840030)资助;2010年度北京大学研究生课程建设经费资助

摘　　要：目的：评价早孕妇女生殖道解脲支原体感染与胚胎停育和反复自然流产发生的风险关联性。方法：在全面回顾文献基础上,分别对检索到的胚胎停育和反复自然流产文献进行数据整理,用Mantel-Haenszel法合并OR值,并进行meta分析。结果：meta分析表明,妇女生殖道解脲支原体感染发生胚胎停育的合并OR值为3.62（95%CI：2.80~4.67）,发生反复自然流产的合并OR值为5.66（95%CI：4.46~7.18）;有有解脲支原体感染史的妇女中,胚胎停育和反复自然流产的发生风险随着其复发次数的增加发生风险逐渐加强。结论：妇女生殖道解脲支原体感染与胚胎停育和反复自然流产之间存在关联,其强度随着复发次数的增加而逐渐加强。有效治疗生殖道解脲支原体感染,对预防育龄妇女不良妊娠结局的再次发生具有重要作用。Objective： To evaluate the efficacy of association between the risk of early pregnant failure and recurrent spontaneous abortion and ureaplasma urealyticum（UU） of reproductive tract infections.Methods： Based on a comprehensive review of literatures,meta-analyses were performed to analyze the data collected from the literatures on early pregnant failure and recurrent spontaneous abortion.A meta-regression analysis was conducted using restricted estimation of maximum likelihood.Odd ratios（OR） was pooled using Mantel-Haenszel method.Results：The risks of early pregnant failure and recurrent spontaneous abortion were associated with UU infection of reproductive tract,the pooled OR were 3.62（95%CI 2.80-4.67） and 5.66（95%CI 4.46-7.18）,respectively.The risks of early pregnant failure and recurrent spontaneous abortion enhanced significantly along with the increasing frequency of UU infection.Conclusion： There was a significant association between the risk of early pregnant failure and recurrent spontaneous abortion and UU infection of reproductive tract,and the association degree enhanced as the recurrent frequency increased among women with UU infection.It suggested that UU infection of reproductive tract should be considered as an important factor in the prevention of early pregnant failure and recurrent spontaneous abortion.

关 键 词：胚胎停育 反复自然流产 解脲支原体 META分析 

分 类 号：R714.21[医药卫生—妇产科学]