甲强龙联合人免疫球蛋白治疗小儿重症手足口病62例效果观察及护理  

Observation on the effectiveness of Methylprednisolone combined with human immunoglobulin in the treatment of 62 children patients with severe hand-foot-mouth disease and nursing care

作　　者：王芳[1] 冯玉梅[1] 汪兰云[1] 

机构地区：[1]聊城市第二人民医院,山东临清252600

出　　处：《齐鲁护理杂志（上旬刊）》2011年第5期24-25,共2页Journal of Qilu Nursing

摘　　要：目的:探讨静脉滴注冲击量甲强龙联合人免疫球蛋白治疗小儿重症手足口病的效果及护理方法。方法:将124例重症手足口病患儿随机分为观察组和对照组各62例,两组均行抗炎、抗病毒及营养支持药物治疗,观察组静脉滴注冲击量甲强龙联合静脉滴注入免疫球蛋白以达到抗炎、促进肺水肿吸收、防治脑水肿、增强免疫的目的;对照组给予小剂量甲强龙静脉滴注。结果:观察组患儿退热、食欲改善、精神症状消失时间均少于对照组,两组比较差异有统计学意义(P<0.01);124例患儿中除1例因病情重转上级医院治疗外,其他经及时救治均痊愈出院。结论:对有重症先兆的手足口病患儿及时应用冲击量甲强龙和人免疫球蛋白能减轻肺水肿,防治脑水肿,阻断肺水肿、脑水肿的恶性循环,有利于疾病恢复。Objective： To explore the effectiveness of intravenous infusion of Methylprednisolone in impulse dose combined with human immunoglobulin in the treatment of children patients with severe hand-foot-mouth disease and nursing methods.Methods： 124 children patients were randomly divided into observation group and control group（62 patients for each group）.The patients in both groups were treated with anti-inflammatory and anti-viral drugs and nutritional supportive therapy.In the observation group,intravenous infusion of methylprednisolone in impulse dose combined with human immunoglobulin was adopted to achieve the purpose of anti-inflammatory effect,promoting absorption of pulmonary edema,preventing cerebral edema and enhancing patient＇s immunity;the small doses of methylprednisolone was intravenously given to the patients in the control group.Results： The body temperature of the children patients returned to normal,appetite improved and mental symptoms disappeared,the differences between the two groups were statistically significant（P〈0.01）.All the other patients recovered except that one patient was transferred to a higher level hospital because of his severe condition.Conclusion： The impulse dose of Methylprednisolone combined with human immunoglobulin applied to the children patients who have premonition of severe symptoms can alleviate pulmonary edema,prevent cerebral edema and block the vicious cycle of pulmonary edema to cerebral edema so as to promote recovery of the children patients.

关 键 词：甲强龙 人免疫球蛋白 手足口病 护理 

分 类 号：R473.5[医药卫生—护理学]