低剂量非那雄胺控制男性型秃发临床观察  

Clinical Effect of Low Doses Finasteride on the Male Pattern Alopecia

作　　者：梁万岗 刘海平 李娜[1] 

机构地区：[1]西安医学院第二附属医院皮肤科,陕西西安710038 [2]深圳明伦整形美容医院,广东深圳518003

出　　处：《中国皮肤性病学杂志》2011年第6期441-443,447,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的通过随机双盲对照试验评估每日口服非那雄胺1mg；台疗2年有效并满意后，减量为5mg/周及1mg隔1日口服治疗中国男性型秃发的疗效、方法选择非那雄胺治疗2年或2年以上的男性型秃发患者175例，随机分为非那雄胺减量治疗组88例和安慰剂对照组87例，分别口服非那雄胺（1～24周5mg／周，24～48周1mg隔日1次口服）或安慰剂48周。并由皮肤科医师在24～48周时对；台疗前、后的头发进行显微照像并评价，同期患者也进行自我评价。结果治疗前、后头发显微照像分析认为．治疗24周时非那雄胺减量治疗组脱发率为48．86％，而安慰剂对照组为98．85％，差异有统计学意义（P〈0．05）治疗48周后非那雄胺减量治疗组的脱发率为73．86％，安慰剂对照组为100％，差异有统计学意义患者在24周和48周时的自我评价的结果也与之相似．结论低剂量口服非那雄胺维持治疗对中国男性型秃发患者脱发有一定作用。Objective To evaluate the efficacy and possibility of oral finastcride（propecia） at doses of 5mg a week and ling qod in the remaining treatment of androgenetic alopecia（AGA） in Chinese men. Methods One hun- dred and seventy-five Chinese men（20- 40 years old） with AGA taking finasteride lmg per day at least 2 years were studied in a randomized, placebo controlled trial. Efficacy of oral finasteride at doses of 5mg a week and I mg qod in the treatment of AGA was evaluated at the end of 24 weeks and 48 weeks by both inde- pendent doctors through micro-photographic review and patients themsleves. Results According to the evaluation of micro-photographs by doctors, the total hair loss rates in finasteride group and placebo group were 48.86% and 98.85% ＇after 24-weeks treatment respectively. There was statistically＇ significant difference between the two groups （ P 〈 0.05）. While after 48-weeks treatment the total hair loss rates were 73.86% and 100% respectively, there were significant difference between the two groups. This result was similar to thai of patients＇ self-assessment. Conclusion Oral finasteride with low dose is effective in maintenance therapy the hair loss in Chinese men with AGA.

关 键 词：非那雄胺 男性型秃发 雄激素源性秃发 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]