选择性5-HT再摄取抑制剂与胃肠道损害的研究进展  

Association between selective serotonin reuptake inhibitors and gastrointestinal damage:advances and prospects

作　　者：姜宗丹[1] 张振玉[1] 钱方[2] 

机构地区：[1]南京医科大学附属南京第一医院消化科,江苏省南京市210006 [2]南京医科大学附属南京第一医院药剂科,江苏省南京市210006

出　　处：《世界华人消化杂志》2011年第13期1375-1380,共6页World Chinese Journal of Digestology

摘　　要：选择性5-羟色胺再摄取抑制剂(SSRIs)是全世界最常见的处方药之一,目前临床上广泛用于抑郁症治疗,与三环类抗抑郁药(TCAs)药效相当,但比TCAs安全且耐受性好.然而,随着SSRIs使用人群的增加,一些病例报道和流行病学研究开始报道SSRIs治疗后出现胃肠道出血并发症.本文就SSRIs的临床应用与胃肠道出血的相关性及其展望进行探讨与综述.Selective serotonin reuptake inhibitors（SSRIs）are among the most commonly prescribed drugs in the world and have widely been used in the treatment of depression,because they have similar efficacy to tricyclic antidepressants and demonstrate a favorable safety and tolerability profile.However,with the increase in the number of patients receiving SSRIs,low-frequency adverse effects associated with use of SSRIs have become more prevalent.Since 1990,a number of case reports and epidemiological studies have described the risk of gastrointestinal bleeding in patients after the initiation of SSRI therapy.This article reviews the recent advances and future prospects for understanding the association between SSRIs and upper gastrointestinal bleeding.

关 键 词：选择性5-羟色胺再摄取抑制剂 胃肠道出血 胃肠道损害 

分 类 号：R595.3[医药卫生—内科学]