2型糖尿病患者应用甘精胰岛素治疗前后内脏脂肪素水平的变化  

Change of plasma visfatin level after insulin glargine therapy in type 2 diabetic patients

作　　者：高谷[1] 李倩[1] 丁波[1] 袁璐[1] 李惠琴[1] 马建华[1] 齐绍康[1] 

机构地区：[1]南京医科大学附属南京第一医院内分泌科,210006

出　　处：《中国糖尿病杂志》2011年第6期401-404,共4页Chinese Journal of Diabetes

基　　金：南京市医学科技发展项目(ZKM06036)

摘　　要：目的探讨应用甘精胰岛素治疗的2型糖尿病患者血浆内脏脂肪素(Visfatin)水平的变化与胰岛素抵抗及血糖的关系。方法共32例2型糖尿病患者,比较其治疗前后空腹(FPG)及餐后血糖(2hPG)、甘油三酯(TG)、糖化血红蛋白(HbA_1c)、空腹胰岛素(FIns)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-)、Visfatin等相关指标。同时选择性别、年龄等相匹配的26名健康体检者作为对照组进行比较。结果32例糖尿病患者治疗前后的TG、FPG、2hPG、HbA_1c、HOMA-IR、HOMA-β差异有统计学意义(P<0.05),治疗后Visfatin水平降低(P<0.05),与健康人相比,糖尿病患者Visfatin水平降低(P<0.01);Pearson相关分析显示Visfatin与HbA_1c、FIns、HOMA-IR呈正相关(r=0.259,P<0.05;r=0.586,P<0.01;r=0.385,P<0.01)。多元线性逐步回归分析表明HOMA-IR是血浆Visfatin的独立相关因素。结论2型糖尿病患者血浆Visfatin水平的变化与胰岛素抵抗及平均血糖有关,可能在糖尿病及胰岛素抵抗的发病机制中具有一定的作用。Objective To explore the relationship of plasma visfatin level with insulin resistance and blood glucose after insulin glargine therapy in type 2 diabetic patients. Methods A total of 32 diabetic patients and 26 healthy controls matched for age and gender were enrolled. Fasting plasma glucose（FPG）, postprandial blood sugar （2hPG）, triglyceride （TG）, glycosylated hemoglobin （ HbA1 c）, fasting insulin （Fins）, insulin resistance index （HOMA-IR）,insulin secretion index （HOMA-β）and plasma visfatin were measured and analyzed. Results There were significant differences in TG, FPG, 2hPG, HbAlc, HOMA-IR and HOMA -β before therapy versus after therapy（P〈0.05）, and plasma visfatin level was reduced after therapy（P〈0.01）. The visfatin level was lower in type 2 diabetic patients than in controls （P〈 0. 01）. Plasma visfatin level was positively correlated with HbA1c,FIns and HOMA-IR （r=0. 259, P〈0.05;r=0. 586,P〈0.01; r=0. 385,P〈0. 01）. Multiple regression analysis showed that HOMA-IR was an independent related factor for plasma visfatin level. Conclusions Plasma visfatin level of type 2 diabetic patients is related to insulin resistance and average blood glucose, which may contribute to insulin resistance and type 2 diabetes mellitus.

关 键 词：甘精胰岛素 糖尿病 2型 内脏脂肪素 胰岛素抵抗 血糖 

分 类 号：R587.1[医药卫生—内分泌]