依托咪酯对布比卡因致惊厥作用的影响  

Influences of etomidate on bupivacaine induced convulsion

作　　者：邱小松[1] 闫肃[2] 戴体俊[2] 吕建农[1] 许铁[1] 

机构地区：[1]徐州医学院附属医院急诊医学科,221004 [2]徐州医学院麻醉学院

出　　处：《中国现代医药杂志》2011年第5期9-11,共3页Modern Medicine Journal of China

基　　金：国家自然科学基金资助项目(编号:30471657;39970715);江苏省自然科学基金资助项目(编号:BK2001143);徐州医学院院课题(编号:09KJ08)

摘　　要：目的观察依托咪酯(etomidate,Eto)对布比卡因(bupivacaine,Bup)致惊厥作用及半数有效量(ED50)、半数致死量(LD50)的影响。方法皮下注射3种不同剂量的依托咪酯20min后,腹腔注射致惊厥作用的布比卡因,观察小鼠惊厥潜伏期、持续时间、未惊厥数和死亡数;并以序贯法测定预先给予依托咪酯20min后布比卡因的致惊厥ED50和LD50。结果依托咪酯2、4mg/kg可延长布比卡因致小鼠惊厥的潜伏期(P<0.01),缩短持续时间(P<0.01),减少惊厥发生数和死亡数;增大布比卡因致惊厥的ED50(P<0.05,P<0.01),增大布比卡因的LD50(P<0.01)。结论依托咪酯能够拮抗布比卡因的致惊厥作用,降低布比卡因的毒性。Objective To observe the influences of etomidate on bupivacaine induced convulsion.Methods Bupivacaine was administered intraperitoneally twenty minutes after etomidate had been administered subcutaneously,observed the convulsant latency period,convulsion duration,incidence of no convulsion and mortality,and analyzed the ED50 and LD50 by sequential method in mice.Results The convulsant latency periods of bupivacaine induced was extended by etomidate,the convulsion duration was shorten,and the incidence of convulsion and mortality were reduced.The ED50 of bupivacaine induced convulsion was raised by etomidate（2,4mg/kg）,the LD50 was raised by etomidate（2,4mg/kg）.Conclusion Etomidate can antagonize the bupivacaine induced convulsion.

关 键 词：依托咪酯 布比卡因 惊厥 ED50 LD50 

分 类 号：R614[医药卫生—麻醉学]