慢性乙型肝炎病毒前S1抗原与HBV-DNA关系分析  

The Pre S1 antigen and HBV-DNA relation analysis of chronic hepatitis B virus

作　　者：石琼[1] 杨丽晖 黄颖红[3] 

机构地区：[1]湖南省疾病预防控制中心,410005 [2]长沙市一医院 [3]湖南省儿童医院

出　　处：《中国现代医药杂志》2011年第5期77-78,共2页Modern Medicine Journal of China

摘　　要：目的探讨乙型肝炎病毒前S1抗原与慢性乙型肝炎患者HBV-DNA的关系,寻找乙肝检测更便捷的方法。方法 125例慢性乙肝患者分别使用PCR法测定HBV-DNA的含量,时间分辨免疫荧光法检测前S1抗原。结果 125例样本中,检出乙型肝炎大三阳60例,检出乙型肝炎小三阳65例,在大三阳与小三阳中,前S1抗原的阳性率与HBV-DNA的阳性率未见显著性差异(P>0.05)。结论 HBV前S1抗原和HBV-DNA有较高的符合率,有很好的相关性,HBV前S1抗原持续阳性代表了疾病的慢性化,甚至发展为肝衰竭、肝硬化及肝癌。Objective To investigate the relation between the Pre S1 antigen and HBV-DNA in chronic hepatitis B virus for finding a more convenient method.Methods 125 patients with chronic hepatitis B were determined HBV-DNA levels by the PCR,the Pre S1 antigen DNA levels by the time-resolved immunofluorescence.Results There were not significantly different between the S1 antigen positive rate and HBV-DNA positive rates（P〉0.05）.Conclusion HBV antigen and HBV-DNA pre S1 has a higher compliance rate,they have good correlation,S1 positive represents chronic diseases,and even the development of liver failure,cirrhosis and liver cancer.

关 键 词：慢性乙型肝炎 肝炎病毒前 S1 抗原 HBV-DNA 

分 类 号：R512.62[医药卫生—内科学]