补肾方对去卵巢大鼠腰椎骨形态计量学的影响  

Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats

作　　者：卢建华[1] 王维佳[1] 陈明涛[1] 华江[1] 万蕾[2] 何剑星[3] 

机构地区：[1]浙江中医药大学附属第一医院,浙江杭州310006 [2]浙江省上虞市中医院,浙江上虞312000 [3]中国人民解放军武装警察部队浙江总队杭州医院,浙江杭州310053

出　　处：《中医正骨》2011年第5期24-26,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：浙江省中医药管理局科研项目(NO.2008CA007)

摘　　要：目的:研究补肾方(左归丸、右归丸)对去卵巢大鼠腰椎骨形态计量学的影响,为补肾方治疗骨质疏松症提供有力的实验依据。方法:将成年SD大鼠50只,随机分为正常对照组、模型组、阳性对照组、左归丸组、右归丸组,每组10只。造模后第13周开始给药,正常对照组、模型组予蒸馏水灌胃,阳性对照组、左归丸组、右归丸组分别予倍美力水溶液、左归丸煎剂和右归丸煎剂灌胃,给药12周末检测第2腰椎骨形态计量学指标。结果:左归丸、右归丸组与模型组比较,腰椎形态计量学指标明显改善(P<0.05),与阳性对照组比较,差异无统计学意义(P>0.05);补肾药物左归丸组与右归丸组比较,差异亦无统计学意义(P>0.05)。结论:补肾方能够抑制骨吸收,减少骨量的丢失,对去卵巢大鼠骨质疏松症具有一定的治疗作用。Objective：To study the Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats,also to provid experimental evidence for treating Osteoporosis.Methods：The 50 Ovariectomized SD Rats were randomly divided into normal control group,model group,positive control（OVX） group,Zuoguiwan and Youguiwan group,each group with 10 Rats,after 12 weeks＇routine feed,normal control group and model group which were intragastric administration with pure water,positive control group which was intragastric administration with conjugated estrogens water-solution,Zuoguiwan group which was intragastric administration with zuoguiwan decocta,Youguiwan group which was intragastric administration with youguiwan decocta,all the rats were intragastric administration following the schedule 12 weeks,then detect the index of morphometry of Second lumbar vertebra.Results：ComPared with model group,Bushenfang（including zuoguiwan and youguiwan） can obviously improve index of morphometry of lumbar vertebra（P0.05）.while there was no statistical significance when compared with positive control group.Meantime,the effect of zuoguiwan group is similar to the youguiwan group（P0.05）.Conclusion：Bushenfang（including zuoguiwan and youguiwan） can obviously improve index of morphometry of lumbar vertebra,decrease the bone resorption,prevent the loss of bone,strengthen bone Vetrebrae,which can prevent and treat osteoporosis.Meantime,the effect of zuoguiwan group is similar to the youguiwan group.

关 键 词：骨质疏松症 左归丸 右归丸 去卵巢大鼠 骨组织形态计量学 

分 类 号：R285.5[医药卫生—中药学]