两种白酒对小鼠海马乙酰胆碱酯酶活性和纹状体单胺类神经递质含量的影响  

EFFECTS OF THE MICE' DEGREE OF DRUNKENNESS ON ACHE ACTIVITY OF HIPPOCAMPUS AND THE CONTENT OF MONOAMINE NEUROTRANSMITTERS IN STRIATUM

作　　者：张梦妍[1] 彭彦卿[1] 党好[1] 李岩[1] 许欣[1] 杜晓昕[1] 饶家权[2] 马斌[2] 杜礼泉[2] 

机构地区：[1]四川大学华西公共卫生学院,成都610041 [2]四川省绵阳市丰谷酒业有限责任公司

出　　处：《现代预防医学》2011年第12期2339-2341,共3页Modern Preventive Medicine

基　　金：四川省科技厅资助项目(2009SZ0101)

摘　　要：[目的]探讨两种白酒对小鼠醉酒表现、海马乙酰胆碱酯酶(acetylcholinesterase,AchE)活性、纹状体多巴胺(dopamine,DA)和5羟色胺(5-hydroxytryptamine,5-HT)含量的影响。[方法]采用48.0%乙醇溶液作为对照组,观察记录两个不同品种白酒对BALB/c小鼠醉酒时间和酒醒时间的影响,比较醉酒时间差异,计算醉酒度百分比。测定对照组、正常组和酒样组小鼠海马AchE活性和纹状体DA、5HT的含量。[结果]两个不同品种的白酒醉酒时间有统计学差异(P﹤0.01),醉酒度百分比分别为145.8%和251.6%。后者醉酒度较低,且小鼠纹状体DA、5-HT含量低(P﹤0.01),海马AchE活性高(P﹤0.05)。[结论]醉酒度低的白酒对海马AchE活性和纹状体DA、5-HT含量的影响较小。[Objective]To investigate two Luzhou-flavor liquors＇ possible effects on mice＇ drunkenness,AchE activity of mice hippocampus and the contents of monoamine neurotransmitters in striatum.[Methods]The ebriety time and sober-up time were observed and recorded among three groups,the control group was administered intragastrically 48.0% ethanol solution and the others were administered two different varieties of Luzhou-flavor liquor with the same line respectively.We compared the difference on the ebriety time and sober-up time,calculate the degree percentage of drunkenness.Meanwhile,we determined the AchE activity of hippocampus and the contents of monoamine neurotransmitters in striatum among the normal group,the control group and two Luzhou-flavor liquors administered groups.[Results]There was statistically difference（P﹤0.001）on ebriety time between two Luzhou-flavor liquor groups,the degree percentages of drunkenness were 145.8% and 251.6%,respectively.The latter had lower degree of drunkenness,and its contents of DA and 5-HT in striatum were lower（P﹤0.01）,and the AchE activity of hippocampus was higher（P﹤0.05）.[Conclusion]The Luzhou-flavor liquor which was identified as having lower degree of drunkenness,had less effects on the AchE activity of hippocampus and the contents of monoamine neurotransmitters in striatum.

关 键 词：醉酒度 多巴胺 5羟色胺 乙酰胆碱酯酶 BALB/C小鼠 

分 类 号：R34[医药卫生—基础医学]