697例慢性荨麻疹患者血清特异性IgE检测分析  

DETECTION AND ANALYSIS OF SERUM SPECIFICITY IGE FOR 697 CHRONIC URTICARIA

作　　者：杨增茹[1] 满永宏[1] 丁雨 张金玉[3] 

机构地区：[1]南阳医学高等专科学校微生物学与免疫学教研室,南阳473058 [2]南阳医专第一附属医院皮肤科 [3]南阳市第一人民医院儿科

出　　处：《现代预防医学》2011年第12期2344-2345,共2页Modern Preventive Medicine

基　　金：河南省科技攻关项目〔0624410101〕

摘　　要：[目的]了解南阳及周边地区慢性荨麻疹过敏原的种类及分布情况,以更好的帮助临床医生对慢性荨麻疹患者进行有效的预防、诊断和治疗,并帮助患者明确发病原因,指导患者改变周围生活环境和饮食习惯,避免再次接触过敏原,减少和防止过敏反应的反复发作。[方法]采用QD(ELISA法)体外过敏原检测系统对697例慢性荨麻疹患者14种吸入性过敏原和11种食入性过敏原的血清特异性IgE抗体进行定性和半定量检测。[结果]引起慢性过敏性荨麻疹最常见的3组吸入性过敏原分别是家尘;尘螨-粉螨;艾蒿-豚草-车前草;其阳性率分别是21.09%、19.66%、10.47%。最常见的3组食入性过敏原分别是大豆-花生;蛋白-蛋黄;虾-蟹,其阳性率分别是12.48%、10.76%、9.04%。[结论]过敏反应是导致慢性荨麻疹发生的重要原因之一,了解本地区常见过敏原,对不同患者采用适宜的方法进行特异性过敏原检测,有利于指导患者不断改善周围环境因素、卫生条件及生活习惯,避免过敏原的再次接触,降低复发率或发病率。[Objective]To learn the types and distrubution of allergens of chronic urticaria in Nanyang and the surrounding area in order to help doctors with effective prevention,diagnosis and treatment.It will help identify the cause of the disease and guide the patients to change the living environment and diet,so as to avoid contacting with allergens and reducing and preventing the repeated bout.[Methods]QD（ELLSA method）vitro allergy testing system was used for detecting serum specificity Ige of 14 inhaled allergens and 11 food allergens of 697 chronic urticaria,and qualitative and semi-quantitative test were used for them.[Results]The three most common inhaled allergens were house dust,dustmites-mite and wormwood-ragweed-plantain;The positive rates were 21.09%,19.66% and 10.47%,respectively.The three most common food allergens were soy-peanuts,protein-egg yolk and shrimp-crab;the positive rate were 12.48%,10.76% and 9.04%,respectively.[Conclusion]Allergic reaction is an important cause of chronic urticaril.Understanding the common allergens in local area and adopting the proper ways to carry out the allergen testing is helpful to guiding the patients to improve the environment,sanitary condictions and living habits,avoide the repeated contact with allergens and reduce relapse rate or morbidity.

关 键 词：慢性荨麻疹 过敏原 特异性IGE 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]