抗毒补心胶囊对缺血缺氧心肌的保护作用  

PROTECTIVE EFFECT OF KANGDUBUXIN CAPSULE ON ANTI-MYOCARDIAL ISCHEMIA

作　　者：吴范武[1] 吕立勋[2] 董小鹏[1] 姚荣妹[1] 王敏[1] 李洁[1] 包巨太[1] 

机构地区：[1]华北煤炭医学院中医学系,唐山063000 [2]华北煤炭医学院药学系

出　　处：《现代预防医学》2011年第12期2355-2356,共2页Modern Preventive Medicine

基　　金：科技部重大新药创制创新药物研究开发项目(2009ZX09103-442)

摘　　要：[目的]研究抗毒补心胶囊对异丙肾上腺素(ISO)致大鼠急性心肌缺血的保护作用及机制。[方法]将60只SD大鼠随机分为正常对照组、缺血模型组、抗毒补心胶囊I组,II组,Ⅲ组,观察抗毒补心胶囊对各组大鼠心电图、血清磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)和脂质过氧化物丙二醛(MDA)的影响。[结果]抗毒补心胶囊可对抗异丙肾上腺素所致的大鼠急性心肌损伤,与模型组比较,抗毒补心胶囊I组,II组,Ⅲ组均使心肌缺血大鼠的心电图ST段异常升高数减少(P﹤0.05),血清磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)降低(P﹤0.05),并可增加SOD的活性(P﹤0.05),减少MDA生成(P﹤0.05)。[结论]抗毒补心胶囊对大鼠心肌缺血有保护作用,其机制可能与抗脂质过氧化反应有关。[Objective]To study the protective effect of Kangdubuxin Capsule on myocardial ischemia induced by isoproterenol（ISO）.[Methods]60 cases of SD rats were divided into normal control group,ischemia model group,Kangdubuxin Capsule I,II and Ⅲgroup,and observed the effect of Kangdubuxin Capsule on the ECG,CK,LDH,SOD and MDA in myocardium.[Results]Kangdubuxin Capsule could protect the acute myocardial injury by isoproterenol.As compared with model group,the frequency of abnormal elevation of STportion in ECG of rats with myocardial ischemia（P﹤0.05）could be decreased,and the levels of LDH,CK andMDA could be decreased and the levels of SOD in serum could be increased（P﹤0.05）.[Conclusion]Kangdubuxin Capsule has protection action on myocardial ischemia of rats,which mechanism may be related to the action of anti lipid peroxidation.

关 键 词：抗毒补心胶囊 异丙肾上腺素 心肌缺血 保护 

分 类 号：R542.2[医药卫生—心血管疾病]