贝那普利对2型糖尿病肾病血清抵抗素水平的影响  

THE EFFECT OF BENAZEPRIL ON SERUM RESISTIN IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY

作　　者：陈小盼[1] 朱洪[2] 宋钦华[1] 郑海龙[1] 孙胜花[1] 李国铨[1] 

机构地区：[1]海南医学院附属医院内分泌科,海口570102 [2]海南医学院附属医院检验科

出　　处：《现代预防医学》2011年第12期2392-2393,2396,共3页Modern Preventive Medicine

基　　金：海南省自然科学基金项目(808237)

摘　　要：[目的]观察贝那普利对2型糖尿病肾病病人血清抵抗素水平的影响及其临床意义。[方法]临床选择研究2型糖尿病病人89例,分为单纯糖尿病组(35例)、糖尿病肾病对照组(30例)和糖尿病肾病治疗组(24例)。所有患者均给予控制血糖药物常规治疗6个月,糖尿病肾病治疗组除控制血糖常规治疗外,还同时给予贝那普利片口服6个月(10mg/d)。各组治疗前后均测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、24h尿白蛋白定量(24hUA)和抵抗素水平。[结果]①治疗前糖尿病肾病对照组、糖尿病肾病治疗组分别与单纯糖尿病组对比,FPG、HbA1c无统计学差异(P﹥0.05),但24hUA和抵抗素水平均有明显升高,差异有统计学意义(P﹤0.05)。而糖尿病肾病对照组与糖尿病肾病治疗组对比,FPG、HbA1c、24hUA和抵抗素水平均无统计学差异(P﹥0.05)。②治疗6个月后糖尿病肾病对照组与单纯糖尿病组对比,两组的FPG、HbA1c均较治疗前明显下降,且两组治疗前后对比下降幅度无统计学差异(P﹥0.05);糖尿病肾病对照组治疗后抵抗素水平明显下降,但下降幅度高于单纯糖尿病组,差异有统计学意义(P﹤0.05);与治疗前对比,糖尿病肾病对照组治疗后24hUA也明显下降。③治疗6个月后糖尿病肾病治疗组与糖尿病对照组对比,两组的FPG、HbA1c均较治疗前明显下降,且两组治疗前后对比下降幅度无统计学差异(P﹥0.05);糖尿病肾病治疗组治疗后24hUA和抵抗素水平明显下降,且下降幅度高于糖尿病对照组,差异有统计学意义(P﹤0.05)。[结论]抵抗素可能在糖尿病肾病的发病中起着重要的作用,血管紧张素转换酶抑制剂通过降低抵抗素水平来改善糖尿病肾病。[Objective]To investigate the effect of benazepril on serum resistin in patients with type 2 diabetic nephropathy.[Methods]89 patients with type 2 diabetic mellitus were divided into three groups：diabetic mellitus group（DM group,n = 35）,diabetic nephropathy control group（DN group,n = 30）and diabetic nephropathy treatment group（DN treatment group,n = 24）.All patients were given conventional treatment of drug to control blood sugar for 6 months,and patients in the DN treatment group were given oral benazepril tablet for 6 months（10mg/day）at the same time.Fasting plasma glucose（FPG）,glycosylated hemoglobin（HbA1c）,24 hour urinary albumin quantitative（24h UA）,and resistin levels were measured before and after treatment in each group.[Results]① Compared to those in the DM group before treatment,FPG,HbA1c was no significant difference（P﹥0.05）,but 24h UA and resistin levels were significantly higher（P﹤0.05）in the DN group and the DN treatment group.There were no significant differences in FPG,HbA1c,24h UA and resistin level between the DN group and the DN treatment group before treatment（P﹥0.05）.② Although compared to those before treatment,FPG and HbA1c decreased significantly in both the DN group and the DM group after treatment for 6 months,the decline in both groups before and after treatment was no significant difference（P﹥0.05）.Resistin level after treatment was significantly decreased in the DN group,and the decline was higher than that in the DM group（P﹤0.05）.Compared with that before treatment,24h UA also decreased after treatment in the DN group.③ FPG and HbA1c decreased significantly in both the DN group and the DN treatment group after treatment for 6 months compared with those before treatment,and the decline in both groups before and after treatment was no significant difference（P﹥0.05）.24h UA and Resistin level significantly decreased in the DN treatment group after treatment,and the decline was higher than that in the DN group（P﹤0

关 键 词：糖尿病 抵抗素 糖尿病肾病 血管紧张素转换酶抑制剂 

分 类 号：R587.1[医药卫生—内分泌]