慢性阻塞性肺病患者血清γ-干扰素水平检测的临床价值  

Clinical Usefulness of Serum IFN γ Level in Patients with Chronic Obstructive Pulmonary Disease

作　　者：陈斌[1,2] 冯玉麟[1] 李双庆[1] 蔡永宁[1] 

机构地区：[1]华西医科大学附属第一医院呼吸内科,成都610041 [2]四川省绵阳市中心医院工作,绵阳621000

出　　处：《华西医科大学学报》1999年第3期304-305,309,共3页Journal of West China University of Medical Sciences

摘　　要：为了解慢性阻塞性肺病患者急性加重期血清γ干扰素水平的变化规律，探讨其在免疫状态评估中的价值。采用放射免疫分析方法，对１５例慢性支气管炎、１５例慢性肺源性心脏病、１５例急性支气管炎患者及１５例健康受试者血清 γ干扰素水平进行检测，并比较慢性支气管炎治疗前后血清 γ干扰素水平的变化。结果显示，与正常对照组比较，血清γ干扰素水平在慢性肺源性心脏病组（０．９３±０．２５ Ｉ Ｕ／ｍ ｌ）变化不大（ Ｐ＞ ０．０５）；慢性支气管炎急性发作期组（１．２３±０．３９ Ｉ Ｕ／ｍ ｌ）亦无明显增加（ Ｐ＞ ０．０５），经治疗后其水平（１．８４±０．５１ Ｉ Ｕ／ｍ ｌ）有显著升高（ Ｐ＜００１）；急性支气管炎组（２．２４±０．７２ Ｉ Ｕ／ｍ ｌ）增高更为显著，并高于其他各组（ Ｐ＜ ０．０１）。提示：在免疫应答反应中血清 γ干扰素水平相对不足，可能是慢性阻塞性肺病患者呼吸道感染反复发作原因之一。血清γ干扰素可作为评估患者免疫功能状态的指标之一。The objective of this study was to gain a clear idea of rule of change in serum IFN γ level in patients with chronic obstructive pulmonary disease and to evaluate the clinical usefulness of IFN γ as a marker of immune condition. The serum IFN γ levels of 15 patients with chronic bronchitis, 15 patients with cor pulmonale, 15 patients with acute bronchitis, and 15 normal subjects were measured by radio immuno assay. Differences between the four groups were tested, and in the chronic bronchitis group, the serum IFN γ levels, before and after treatment were compared. The results showed that compared with the normal group (0.8±0.17 IU/ml), the serum level changed little in the cor pulmonale group (0.93±0.25 IU/ml); it was not higher in the chronic bronchitis group (1.23±0.39 IU/ml, P >0.05), but it went up significantly after treatment for 7 days (1.84±0 51 IU/ml, P <0.05). The highest level of IFN γ was noted in the acute bronchitis group (2.24±0.71 IU/ml, P <0.01). There was a significant difference compared with other groups ( P <0.01). These results suggest that relative deficiency of serum IFN γ may be a factor inducing repeated respiratory infection, and the serum level of IFN γ can be used as an index to assess the immune condition of patients with chronic obstructive pulmonary disease.

关 键 词：阻塞性肺疾病 Γ-干扰素 血清诊断 

分 类 号：R563.904[医药卫生—呼吸系统] R446.112[医药卫生—内科学]