鼻咽部表面活性物质与分泌性中耳炎关系的研究  

The Relationship between Nasopharynx Surface active Agents and Otitis Media Effusion

作　　者：邱丽华[1] 秦学玲[1] 付艳军[1] 郑芸[1] 

机构地区：[1]华西医科大学附属第一医院耳鼻咽喉科,成都610041

出　　处：《华西医科大学学报》1999年第3期310-311,353,共3页Journal of West China University of Medical Sciences

基　　金：四川省科委科研基金

摘　　要：作者随机选择分泌性中耳炎（ Ｏ Ｍ Ｅ）患者４０例为观察组，另选择健康成人及儿童４０例为对照组。用分光光度计法定量测定正常人及 Ｏ Ｍ Ｅ患者鼻咽部灌洗液中代表表面活性物质的卵磷脂含量，间接反映其表面活性物质的量，以探讨 Ｏ Ｍ Ｅ的发病机理和新的治疗方法。结果显示， Ｏ Ｍ Ｅ患者鼻咽部灌洗液中卵磷脂含量为８６３７±２．７３０ｍ ｇ／ Ｌ，较正常对照组３９．２１２±２．４３７ｍ ｇ／ Ｌ 明显减少（ Ｐ＜ ０．０１ ），儿童患者其卵磷脂含量为８．０６２±２９２５ｍ ｇ／ Ｌ较正常同龄对照组３９．７８７±２．５５７ｍ ｇ／ Ｌ显著减少（ Ｐ＜ ０．０１ ），表面活性物质含量与病程无明显相关。以上提示：局部表面活性物质减少可能是 Ｏ Ｍ Ｅ发病机理之一，外源性表面活性物质的应用和促进内源性表面活性物质的分泌可能为预防和治疗 Ｏ Ｍ Ｅ提供一条新途径。This experiment was done with a view to exploring the etiologic mechanism and new therapy of otitis media effusion (OME). The amount of lecithin, which is representative of the surfactants in the nasopharynx irrigation wash liquid, was determined by photometry in 40 cases OME and 40 normal controls. The results showed the surfactant of otitis media effusion (8.637±2.730mg/L) was significantly lower than that of normal (39.212±2.437mg/L) in the nasopharynx irrigation wash liquid ( P <0.01). The surfactant of child group of OME (8.062±2.925mg/L) significantly lower than that of normal control(39.787±2.557mg/L, P <0.01). The surfactant of otitis media effusion in the nasopharynx irrigation wash liquid was not associated with the course of OME. These data suggest that the surfactant reduction in the nasopharynx could indirectly reflect the level of the surfactant in the eustachian tube and the middle ear and influence the eustachian tube function. Surfactant reduction may be one of the etiologic mechanisms of OME. Increasing the surfactant in the nasopharynx and eustachian tube could be beneficial to reducing the persistent otitis media effusion.

关 键 词：分泌性 中耳炎 表面活性物质 鼻咽部 

分 类 号：R764.210.2[医药卫生—耳鼻咽喉科]