肝靶向米托蒽醌聚乳酸缓释毫微粒冻干针剂兔体内药代动力学研究  

Study on the Pharmacokinetics of the Liver Targeted Mitoxantrone Polylactic Acid Extended release Nanoparticles in Rabbits

作　　者：徐超群[1] 廖工铁[1,2] 王双 张志荣[1] 

机构地区：[1]华西医科大学药学院药剂学教研室,成都610041 [2]四川省中药研究所

出　　处：《华西医科大学学报》1999年第3期337-339,共3页Journal of West China University of Medical Sciences

摘　　要：用 Ｈ Ｐ Ｌ Ｃ法测定米托蒽醌普通制剂和聚乳酸毫微粒靶向制剂兔耳静脉给药后经时血药浓度，并用３ Ｐ８７ 药动学模型计算其药动学参数，以此探讨并比较靶向制剂与普通制剂血药浓度的经时变化规律。结果显示：上述两种制剂兔血药时间曲线均符合三室模型，计算所得的理论药物浓度和实测药物浓度契合良好。靶向制剂改变了药物的吸收和消除过程，具有延效和缓释作用。HPLC was used to analyse the drug concentrations in blood. The 3p87 (practical pharmacokinetic program version) was used to calculate the parameters of DHAQ PLA NP lyophilization injection and DHAQ injection through iv administration in rabbit blood. The concentration time curves of the two kinds of preparations were in keeping with the three compartment model. The drug concentrations were calculated according to the selecting pharmaceutical model and parameters. The calculated drug concentrations agreed well with the observed. The lyophilization injection sustained the eliminating process in vivo.

关 键 词：聚乳酸 缓释毫微粒 药代动力学 米托蒽醌 兔 

分 类 号：R979.1[医药卫生—药品] R969.1[医药卫生—药学]