肝素小剂量泼尼松和阿斯匹林治疗妊娠抗磷脂综合征  

Heparin with Low Dose of Prednisone or Aspirin Therapy for Pregnant Women with Antiphospholipid Syndrome

作　　者：苑雅茹[1] 朱楣光[2] 唐志明[2] 李淑敏[2] 

机构地区：[1]天津塘沽医院妇产科,300450 [2]天津市中心妇产科医院,300052

出　　处：《中国实用妇科与产科杂志》1999年第9期549-550,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨治疗抗磷脂综合征妇女反复妊娠流产和死胎的有效方法。方法　抗磷脂抗体阳性者采用小剂量阿斯匹林75mg 每日一次口服2 周,9 例抗体持续阳性者改用肝素6 250IU 每12 小时1 次皮下注射及泼尼松5mg每日1 次口服至抗体阴性停用。结果　9 例患者中有8 例胎儿存活,平均孕周为36 周,无与药物有关的严重并发症。结论　肝素的使用可增加围产期胎儿存活率,结果证实上述三种药物的小剂量合理应用是安全有效的。Objective\ To establish effective treatment for pregnant women with antiphospholipid syndrome of recurrent pregnancy loss and fetal death.Methods\ The patients with antiphospholipid antibodies were treated with low dose of asprin 75mg,q.d.for 2 weeks.Nine patients with the antibodies persistant positive were treated by heparin 6250 IU,q.4h.subcutaneous injection and low dose of prednisone 5mg,qd.instead of asprin.The later two drugs were used until the antibodies disappeared.Results\ Eight of 9 patients resulted in living births at a mean gestational age of 36 weeks without serious drug-related complications.Conclusion\ The use of heparin raises perinatal living birth rate.The results prove that rational use of low dose of heparin,prednison and asprin is safe and effective.

关 键 词：抗磷脂综合征 肝素 阿斯匹林 妊娠合并症 

分 类 号：R714.256[医药卫生—妇产科学] R589.205[医药卫生—临床医学]