辛伐他汀对隐匿性高血压患者内皮功能的影响  

Effects of simvastatin on endothelial function in patients with masked hypertension

作　　者：傅坤发[1] 蒋益波[2] 胡建[1] 赵慧娟[1] 

机构地区：[1]江苏省老年医院 江苏省老年医学研究所老年科,南京市210024 [2]江苏省泰兴市人民医院心内科

出　　处：《中国心血管病研究》2011年第6期413-416,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨辛伐他汀对隐匿性高血压患者血管内皮功能的影响.方法 根据动态血压和诊室偶测血压将研究对象分为隐匿性高血压组（MH组,35例）和正常血压组（NT组,30例）.所有入选者均测定血清非对称性二甲基精氨酸（AMDA）、可溶性血管细胞间黏附分子-1（sVCAM-1）及主要的血清生化指标,并通过彩色多普勒超声测定颈动脉内膜中层厚度（IMT）.MH组给予辛伐他汀20 mg/晚,共8周,然后再复查上述指标.结果 MH组血清ADMA、sVCAM-1和颈动脉IMT均显著高于NT组（P＜0.01）;MH组治疗前后比较,血清ADMA和sVCAM-1显著下降（P＝0.024,P＝0.038）,而颈动脉IMT减少无统计学意义（P＝0.08）.直线相关分析显示,MH组治疗前的血清ADMA（r＝0.68,P＜0.01）、sVCAM-1（r＝0.63,P＜0.01）与颈动脉IMT具有直线正相关.结论 MH患者存在血管内皮功能障碍和颈动脉硬化,辛伐他汀可以改善MH患者血管内皮功能.Objective To study the effects of Simvastatin on endothelial function in patients with masked hypertension. Methods All subjects were classified into masked hypertension group （group MH, n=35） and normotension group （group NT, n=30）. All patients in group MH were prescribed 20 rag/day of Simvastatin. Serum asymmetric dimethylarginine （ADMA）, soluble vascular cell adhesion molecule-1 （sVCAM-1 ）, biochemical parameters and carotid intima-media thickness （IMT） were measured at baseline in all subjects and aider 8 weeks of treatment in group MH. Results Serum ADMA（3.34±0.88） vs （2.73±0.52） umol/L, serum sVCAM-1（872.9± 197.5） vs （781.1±162.6） ng/ml, and carotid IMT （0.95±0.21） vs （0.81±0.11）mm were singnificantly higher in group MH than those in group NT （P〈0.01, respectively）. After treatment in group MH, the levels of serum AD- MA[（3.34±0.88） vs （2.87±0.85） umol/L, P=0.024] and sVCAM-1[（872.9±197.5） vs （781.1±162.6）ng/ml, P=0.038] were singnificantly decreased, but no significant difference existed in carotid IMT（P=0.08）. Serum ADMA and sVCAM-1 were positively related with carotid IMT in group MH （r=0.68, P〈0.01, and r=0.63, P〈 0.01 ）. Conclusion Endothelial dysfunction and carotid atherosclerosis were existed in MH patients, and Simvastatin could improve endothelial function in these patients.

关 键 词：隐匿性高血压 辛伐他汀 非对称性二甲基精氨酸 血管细胞间黏附分子 

分 类 号：R544.1[医药卫生—心血管疾病]