小剂量螺内酯抑制急性前壁心肌梗死患者的左室重构  

Effects of low-dose spironolactone on inhibition of left ventricular remodeling in patients with acute anterior myocardial infarction

作　　者：马京炬[1] 亢惠兰[1] 郑跃星[1] 胡菁[1] 

机构地区：[1]临汾市人民医院心内科,山西省041000

出　　处：《中国心血管病研究》2011年第6期423-425,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨小剂量螺内酯对急性前壁心肌梗死患者血清脑利钠肽（BNP）水平和左室重构的影响.方法 选择急性前壁心肌梗死患者90例,在常规治疗基础上,随机分为3组：常规治疗组30例,接受转换酶抑制剂、β受体阻滞剂、抗血小板、调脂药物等常规处理;小剂量螺内酯组30例,在上述治疗基础上每日给予螺内酯20 mg;中剂量螺内酯组30例,在上述治疗基础上每日给予螺内酯40 mg.结果 6个月时小剂量螺内酯组、中剂量螺内酯组和常规治疗组左室射血分数显著升高（P＜0.05）.治疗后常规治疗组BNP水平显著下降（P＜0.05）,小剂量螺内酯组和中剂量螺内酯组BNP水平下降更显著（P＜0.01）;小剂量螺内酯组与中剂量螺内酯组比较差异无统计学意义.结论 小剂量螺内酯抑制急性前壁心肌梗死患者的左室重构,血清BNP水平下降.Objective To investigate the effects of spironolactone on the level of serum brain natriuretic peptide and left ventricular remodeling in patients with acute anterior myocardial infarction. Methods 90 patients with acute anterior myocardial infarction patients in conventional therapy, were randomly divided into 3 groups, the conventional treatment group（30 patients received converting enzyme inhibitors, 13 blockers, antiplatelet, lipid lowering drugs）, small dose of spironolactone（n=30, daily spironolactone 20 mg） and medium dose of spironolactone group（n=30, spironolactone 40 mg）. Results At 6 months, left ventricular ejection fraction was significantly higher in spironolactone group than conventional treatment group （all P〈0.05） and BNP levels were significantly decreased （P〈0.05）, there was no different between low-dose and medium dose spironolactone group in the levels of BNP. Conclusion Low-dose spironolactone shows inhibition of left ventricular remodeling in patients with acute anterior myocardial infarction. BNP levels were decreased.

关 键 词：心肌梗死 前壁 急性 左室重构 螺内酯 脑钠肽 

分 类 号：R542.22[医药卫生—心血管疾病]