氨苄青霉素/丙磺舒胶囊的临床疗效与安全性研究  

A Study on the Efficacy and Safety of Ampicillin/Probenecid

作　　者：何庆[1] 徐大华[1] 秦莉[1] 冯惠荃 梁德荣[1] 王浴生[1] 

机构地区：[1]华西医科大学附属第一医院急诊科,成都610041

出　　处：《华西医学》1999年第3期285-287,共3页West China Medical Journal

摘　　要：采用随机对照多中心临床研究 ,使用氨苄青霉素 /丙磺舒胶囊治疗急性细菌性感染患者 10 4例。其中 5 0例与进口氨苄青霉素胶囊治疗同类患者 5 0例进行随机对照试验 ;5 4例为开放性试验。试验组和对照组痊愈率与有效率均无显著性差异。试验组细菌清除率为 86 7% ,与对照组虽无显著性差异 ,但其耐药率为 7 1% ,低于对照组。不良反应发生率为 5 0 %。结果表明氨苄青霉素 /丙磺舒胶囊是一高效、安全的抗菌素。In this multicenter clinical trial,the authors studied the effect of ampicillin/probenecid on acute bacterial infection.A total of 154 patients were recruited.The first 100 patients were randomized into either the study group,or the control group,taking imported ampicillin.Another 54 patients were in open trial,taking the studied medicine.There was no significant difference between the study and control groups in complete recovery rate and effective rate.The rate of bacterial clearance was 86 7% in the study group,not significantly different from the control group.However,the rate of bacterial resistance in the study group was 5 1%,lower than that of the control.The incidence of adverse drug reaction was 5 0% in the study group.We conclude that ampicillin/Probenecid is a safe antibiotic with high efficacy.

关 键 词：氨苄青霉素 丙磺舒 细菌性感染 安全性 

分 类 号：R515.05[医药卫生—内科学] R978.1[医药卫生—临床医学]