肝胆功能显像的定量分析在评价胆道疾病中的价值  

The Value of Quantitative Analysis in Hepatobiliary Function Imaging for Evaluating the Biliary Tract Diseases

作　　者：杜明华[1] 杨德同[1] 史留斌[1] 韩笑苇[1] 

机构地区：[1]南京铁道医学院附属医院核医学科胆道外科,南京210009

出　　处：《华西医学》1999年第3期291-293,共3页West China Medical Journal

摘　　要：20例正常人 ,6 3例肝胆患者进行99mTc -EHIDA动态功能显像定量分析 ,利用 90分钟的动态图象 ,建立肝感兴趣区的时间放射性曲线 ,计算肝脏泌胆分数 (HEF) ,半排时间 (TEX) ,高峰时间 (Tup)利用脂餐刺激内源性cck释放 ,计算排胆分数 (GBEF) ,排胆期 (GBEP) ,排胆率 (GBER)。结果 :正常受试者与胆汁淤积组肝脏泌胆功能 ,胆囊运动功能测定的比较 ,显示正常人与胆汁淤积组之间有显示差异 ,P <0 0 5 ;胆汁淤积组GBEP、GBEF、GBER、HEF均较正常人明显降低 ,Tex、Tup明显延长 ;手术前后肝脏 (HEF)胆囊 (GBEF)的比较显示手术后肝 ,胆功能明显改善 ;核素显像与B超比较 ,除胆石症B超诊断准确率明显高于核素显像 ,胆管炎 ,慢性胰腺炎 (胆源性 ) ,胆道肿瘤差别不大 ;胆道畸形 ,Oddi括约肌功能梗阻核素显像显示高于B超。因此 。The quantitative analysis of Tc-99m-EHIDA kinetic function imaging was carried out in 20 normal controls and 63 patients with hepatobiliary diseases.The time-radioactivity curve was obtained from ROI’,which was developed from the kinetic imaging after 90 min.Based on the curve,HBF,TEX,and TUP were respectively calculated,and the GBEF,GBEP and GBER were also calculated after the fat meal simulating the intrinsic CCK delivery.Results:To compare normal control with cholestasia group showed that there was significant difference between two groups ( P <0 05);the GBEP,GBEF,GBER and HEF in patients with biliation were less than that of normal control;the TEX and TUP showed significant extension in patients.To compare HEF with GBEF before and after operation showed that there were signif icant improvement in hepatobiliary function.The comparison between radionuclide imaging and ultrasonography showed that there was no difference in diagnosing cholangeitis,chronic pancreatitis and biliary tract tumor,but the accuracy of ultrasonography was higher than that of raionuclide imaging in diagnosing cholelitheasis and the accuracy of radionuclide imaging was higher than that of the ultrasonography in diagnosing the deformity of biliary tract and the functional obstruction of Oddi’s sphinter.It can be concluded that the quantitative analysis of hepatobiliary function imaging in diagnosing the biliary tract diseases is of great significance.

关 键 词：胆道疾病 肝胆功能显像 放射性核素显像 

分 类 号：R657.404[医药卫生—外科学] R817.45[医药卫生—临床医学]