核黄素和川芎嗪对大鼠氧反常心脏作用的比较  

A Comparison of the Protective Effect of Riboflavin and Tetramethylpyrazine(TMP) on Paradoxical Oxygen Damage on Isolated Perfused Rat Heart

作　　者：杨会杰 赵国胜 周志泳 左保华 

出　　处：《皖南医学院学报》1999年第3期165-167,共3页Journal of Wannan Medical College

摘　　要：离体大鼠心脏缺氧灌注１５ｍ ｉｎ 后，复氧再灌１５ｍ ｉｎ，可诱发氧反常损伤的疾病模型。结果表明，Ｒ和Ｔ组心肌组织ＳＯＤ活性后者显著高于前者（Ｐ＜ ０．０５），心肌ＭＤＡ含量则低于前者（Ｐ＜ ０．０５）。此外核黄素和川芎嗪还能降低心律失常发生率，提示核黄素和川芎嗪对氧反常心脏均有明显保护作用。After a 15 min of anoxic Krebs-henseleit(K-H)buffer followed by a 15 min of normal K-H buffer reperfusion , paradoxical oxygen damage models were induced. The results showed that activity of superoxide dismutase (SOD)was markedly higher(P<0.05)while the content of myocardial malondialdehyde(MDA) was markedly lower(P<0.05) in Group B and T than in Group R and incidences of reperfusion arrhythmias were reduced by riboflavin and TMP. It is concluded that riboflavin and TMP have significant protective effect on oxygen paradox-induced injury in isolated rat heart.

关 键 词：核黄素 川芎嗪 大鼠 氧反常心脏 心血管病 

分 类 号：R541[医药卫生—心血管疾病] R594.306[医药卫生—内科学]