抗生殖免疫抗体及性激素与子宫内膜异位症发病的关系研究  

Association of anti-reproductive immunoassay antibodies and changes of gonadal steroids hormones in endometriosis

作　　者：杨艳萍[1] 逯静茹 关志宝 张学艳[1] 李静[1] 

机构地区：[1]河北省秦皇岛市海港医院检验科,066000

出　　处：《中国误诊学杂志》2011年第17期4038-4040,共3页Chinese Journal of Misdiagnostics

摘　　要：目的探讨患者抗生殖免疫抗体及性激素的变化与子宫内膜异位症(endometriosis,EMS)发病的关系。方法回顾性分析268例EMS患者(其中年龄>35岁组的EMS患者90例;年龄≤35岁组的EMS患者178例)和200例非子宫内膜异位症患者(其中年龄>35岁组的非子宫内膜异位症患者72例,为同龄对照组;年龄≤35岁组的非子宫内膜异位症患者128例,为同龄对照组)的临床资料。用化学发光免疫分析法检测两组患者血清卵泡刺激素(follicle-stimulating homone,FSH)、黄体生成素(homone,LH)、睾酮(testosterone,T)、雌二醇(estradiol,E2)孕酮(progesterone,P)和泌乳素(prolactin,PRL)水平;采用酶联免疫法检测抗卵巢抗体(anti-ovarian antibodies,AO-Ab)、抗心磷脂抗体(anticardiolipin antibody,ACL)、抗子宫内膜抗体(anti-endometrial antibodies,EMAb)水平。结果年龄>35岁组和年龄≤35岁组EMS患者的P、PRL水平均高于同龄对照组,差异有统计学意义;年龄>35岁组的EMS患者LH水平也显著高于同龄对照组,差异也有统计学意义(P<0.05)。其他激素各项指标比较,差异无统计学意义(P>0.05)。年龄>35岁组和年龄≤35岁组EMS患者的抗生殖免疫抗体AOAb、ACL、EMAb阳性率明显高于同龄对照组,差异有统计学意义(P≤0.05)。结论 ENS患者存在抗生殖免疫抗体变化,高孕激素、高泌乳素水平可能与EMS发病有关。Objective To explore the association between anti-reproductive immunassay antibodies and changes of gonadal steroids hormones in endometriosis.Methods We retrospectively analyzed the clinical data of 268 patients with endometriosis（endometriosis group aged35 years old,90 cases;endometriosis group aged≤35 years old,178 cases）and 200 patients with non-endometriosis were retrospectively analyzed（patients control group aged35 years old,72 cases;patients control group aged≤35 years old,128 cases）.Chemiluminescence immunoassay was used to detect the levels of serum luteninizing,follicle stimulating homone（FSH）,homone（LH）,testosterone（T）,estradiol（E2）,progesterone（P）and prolactin（PRL）.The serum levels of anti-ovarian antibodies（AoAb）,anticardiolipin antibody（ACL）and anti-endometrial antibodies（EMAb） were detected by enzyme linked immunosorbent assay（ELISA）.Results The endometriosis group aged35 years old and aged≤35 years old showed higher serum P and PRL level,significantly higher reproductive autoantibody positive rate than control group endo aged35 years old and aged≤35 years old.The serum LH was significantly higher in endometriosis group B than that of control group aged35 years old（P0.05）.Comparison of the indicators of other hormones,there was no significant difference（P0.05）.Conclusion The result suggests that there exist anti-reproductive immunoassay autoantibodies changes in endometriosis patients.Higher P and higher PRL levels may play a role in the pathogenesis of endometriosis.

关 键 词：自身抗体 性腺甾类激素 子宫内膜异位症/免疫学 

分 类 号：R711.71[医药卫生—妇产科学]