曲美他嗪对非体外循环冠脉搭桥术患者IL-6、IL-8的影响  

Efects of Trimetazidine On-pump Coronary Artery Bypass Grarting in Patients with IL-6,IL-8

作　　者：宋书田[1] 张彬[2] 张楠[1] 杨明[1] 白传明[1] 周继梧[1] 

机构地区：[1]河北医科大学附属沧州市中心医院心胸外科,沧州061001 [2]河北医科大学附属沧州市中心医院麻醉科,沧州061001

出　　处：《中国医药导刊》2011年第4期631-632,共2页Chinese Journal of Medicinal Guide

基　　金：河北省科技支撑计划项目;项目编号:10ZD96

摘　　要：目的:观察曲美他嗪对非体外循环冠状动脉(冠脉)旁路移植术(of-pump coronary artery bypass,OPCAB)患者白介素6(interleukin-6,IL-6)和白介素8(interleukin-8,IL-8)浓度的影响。方法:将103例于我院择期行OPCAB的冠心病患者随机分为曲美他嗪组(52例)和对照组(51例)。分别于术前、吻合旁路血管开放后6h、12h、24h、48h抽取静脉血,采用放免法检测血清IL-6和IL-8浓度。结果:2组患者临床特征及手术桥血管情况无统计学意义。曲美他嗪组IL-6浓度在术后6h[(225±16)、(515±81)ng/L]和术后12h[(172±5)、(285±11)ng/L]明显低于对照组(P<0.05)。曲美他嗪组的IL-8浓度在术后12h[(638±30)、(893±59)ng/L]和24h[(497±16)、(589±26)ng/L]显著低于对照组(P<0.01)。结论:曲美他嗪可降低OPCAB患者IL-6和IL-8的释放。Objective：To observe the effects of trimetazidine on serum of the patients ,interleukin-6 and interleukin-8 underwent offpump coronary artery bypass.Methods：One hundred and three patients who underwent off-pump coronary artery bypass randomly divided into trimetazidine group（52 cases） and control group（51 eases）.To draw vein blood preoperative,postoperative six hours,postoperative twelve hours,postoperative twenty-four hours and postoperative forty-eight hours for analyze interleukin-6 and interleukin-8.Results：There was no significant difference between two groups of clinical characterizes and grafts.The serum interleukin-6 of trimetazidine group was lower than control group after surgery six hours and twelve hours, respectively（P〈0.05）. The serum interleukin-8 of trimetazidine group was lower than control group after surgery twelve hours and twenty-four hours, respectively（P〈0.01）.Conclusion：Trimetazidine may reduce the release of the serum level of interleukin-6 and interleukin-8 the patients underwent off-pump coronary artery bypass.

关 键 词：曲美他嗪 冠状动脉旁路移植术 非体外循环 白细胞介素类 

分 类 号：R654.2[医药卫生—外科学]