重度子痫前期肾小球滤过功能改变的临床分析  

Clinical analysis on change of glomerular filtration function of patients with severe preeclampsia

作　　者：赵君[1] 刘海意[1] 李宇琪[1] 杜慧[1] 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《中国妇幼保健》2011年第17期2596-2597,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨重度子痫前期肾小球滤过功能损伤的相关情况及对妊娠结局的影响。方法:回顾性分析112例重度子痫前期患者血清肌酐、高血压、蛋白尿及妊娠结局。结果:在重度子痫前期患者中,血清肌酐升高占总例数的30.4%;肌酐改变对血压无显著影响;尿蛋白丢失严重及胎儿窘迫时,肌酐浓度显著升高。结论:重度子痫前期肾小球滤过功能损伤较常见,该损伤可能引起尿蛋白丢失加重及不良妊娠结局,因此,阐明其发生机制有着重要意义。Objective：To explore the related situations of injury of glomerular filtration function of patients with severe preeclampsia and its effect on pregnancy outcomes.Methods：The serum creatinine,hypertension,proteinuria and pregnancy outcomes of 112 cases with severe preeclampsia were analyzed retrospectively.Results：Among 112 cases with severe preeclampsia,the proportion of patients with increasing serum creatinine was 30.4%,the change of serum creatinine level had no significantly impact on blood pressure;the serum creatinine level of patients with severe urine proteins loss and fetal distress increased significantly.Conclusion：The injury of glomerular filtration function of patients with severe preeclampsia is common,which can induce the aggravation of urine proteins loss and adverse pregnancy outcomes.Therefore,clarifying the mechanism has important significance.

关 键 词：重度子痫前期 肾小球滤过功能 血清肌酐 尿蛋白 妊娠结局 

分 类 号：R714.24[医药卫生—妇产科学]