高效液相色谱法测定双氯芬酸钠分散片的含量  

Determination of dispersible diclofenac sodium tablets by HPLC

作　　者：谷福根[1] 吴春芝[1] 柳翠敬[2] 

机构地区：[1]内蒙古蒙医学院,通辽028041 [2]北京医科大学药学院

出　　处：《中国医院药学杂志》1999年第9期535-536,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的：测定双氯芬酸钠分散片的含量。方法：采用高效液相色谱法（HPLC），其测定条件为YWG－C18色谱柱，甲醇-水-36％（V／V）醋酸（70：30：2）为流动相，检测波长为260nm，非那西丁为内标。结果：双氯芬酸钠在5.03～50.25mg·L-1，浓度范围内线性关系良好（γ＝0.9999），平均回收率为100.8％（RSD＝0.4％,n＝5）。结论：该法简便、灵敏、准确。To determine diclofenac skdium(DFS) in dispersible tablets. METHODS: A reversed-phase HPLC wasestablished for determination of the dispersible tablets by using YWG-C18 column and phenacetin as the internal standard. The mobilephase consisted of methanol, water and 36 % (v/v) acetic acid(70 : 30 : 2 ) and the detection wavelength was 260 nm. RESULTS: DFShad a good linearity(r = 0. 999 9) ranging frorm 5. 03 ~ 50. 25 mg' L- 1, whiIe the mean recovery was 100. 8% (RSD = 0. 4 %, n =5 ). CONcLUSIONS: The above method is simple, sensitive, accurate and rapid.

关 键 词：双氯芬酸钠 高效液相色谱法 分散片 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]