中药有效成分逆转白血病细胞多药耐药研究进展  

Advances of reversing hematological cells multidrug resistance by active components of materia medica

作　　者：司叶俊[1] 沈群[2] 季鸥[1] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]南京中医药大学第一附属医院血液科,江苏南京210029

出　　处：《上海中医药杂志》2011年第6期92-96,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：江苏省卫生厅"科教兴卫工程"医学重点人才课题(RC2007068)

摘　　要：概述近年来中药有效成分逆转白血病细胞多药耐药(mu ltidrug resistance,MDR)的研究进展。MDR是白血病治疗失败的主要原因之一,而中药具有多靶点、低毒、高效等作用特点,可通过多个途径有效逆转MDR,其中以中药有效成分靶向调节MDR相关蛋白和因子为研究热点。This paper summarizes the progress on reversing multidrug resistance（MDR） in leukemia by components in Chinese herbs.MDR is the main reason for failure of leukemia treatment.With multi-target point,low-level toxicity and efficiency,traditional Chinese medicine（TCM） can reverse MDR form several ways,among which TCM targeting to regulate MDR-related proteins and factors was researched as the hot point.

关 键 词：中药有效成分 白血病 耐药逆转 综述 

分 类 号：R285.5[医药卫生—中药学]