动物唾液腺功能组分研究进展  

Progress on the Functional Components Salivary Gland in Animals

作　　者：谢鹏[1,2] 赵春晖[1] 李庆伟[2] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116029 [2]辽宁师范大学海洋生物功能基因与蛋白质组学研究所,辽宁大连116029

出　　处：《动物医学进展》2011年第6期134-138,共5页Progress In Veterinary Medicine

基　　金：辽宁省教育厅科学技术研究项目(2009A413);大连市科学技术基金项目(2008J22JH010)

摘　　要：动物在长期进化过程中,其唾液腺经过不断演化而分泌具有各种生理活性的功能组分,并对机体产生多重作用。随着生物毒素成为新的研究热点,近年来对动物唾液腺分泌功能组分的研究也越来越深入。在吸血节肢动物、无颌类动物、有毒动物以及吸血蝙蝠的唾液腺分泌物中不断发现大量新的功能组分,其中包括抗凝、抗炎、抗肿瘤和抑菌等多种活性分子。除了对这些活性分子进行分离纯化及结构鉴定之外,它们的功能机制也被广泛深入的研究。同时,这些功能组分的药用和临床应用研究也取得了一定成果,被开发和研制成各种新型临床诊断试剂、治疗药物以及基因工程产品。The salivary glands of many animals produced a diversity of venoms and secretions to adapt the changes of environments during the long history of evolution.In the secretions of the salivary gland of blood-feeding arthropods,jawless vertebrates,venomous animals and vampire bats,many novel functional components have been found,which showed anti-coagulation,anti-inflammation,anti-tumor,bacteriostasis and other activities.These components were separated and purified,and their functions were well stu-died.Some progress has been made in the development of pharmaceutical values and clinical application.The various new clinical diagnostic reagents,drugs and gene engineering products have been developed,which hold great promise in treatment of diseases in the future.

关 键 词：动物 唾液腺 分泌物 功能组分 应用 

分 类 号：S852.2[农业科学—基础兽医学]