病毒感染与自由基的相互作用  

Interaction of Virus Infection and Free Radicals

作　　者：刘倩[1] 严玉霖[1,2] 高洪[1] 高利波[1] 赵汝[1] 

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650201 [2]中国农业科学院家畜疫病病原生物学国家重点实验室,甘肃兰州730046

出　　处：《动物医学进展》2011年第6期167-170,共4页Progress In Veterinary Medicine

基　　金：家畜疫病病原生物学国家重点实验室开放基金(SKLVEB2009KFKT009);云南省高端科技人才引进项目(2009CI125);云南省现代农业生猪产业技术体系建设(云财农[2009]171号)

摘　　要：近年来,在基础医学和生命科学领域对自由基的研究已成为一个热点。随着研究的不断深入,自由基已经介入到许多病毒感染性疾病的致病过程,对疾病的发生、发展起着重要作用。病毒可诱导宿主细胞产生氧化应激,释放大量活性氧自由基,在活性氧自由基的作用下病毒复制增强。同时过多的自由基作用于机体,会造成生物膜的脂质过氧化损伤,引起酶、氨基酸、蛋白质的氧化破坏等,从而引起机体的损伤,导致疾病。目前研究发现多种病毒的感染与自由基的产生存在着一定的相关性,论文就自由基的产生以及与病毒感染的关系做一综述。In recent years,the research on free radicals has become a hot topic in basic medicine and life science.With futher studies,people discovered that the free radicals participated the pathopoiesis process and played a key role in viral infectious diseases.Virus could induce host cells producing oxidative stress and releasing lots of reactive oxygen species,which contributes to the viral replication.An excess of free radicals could cause the lipid peroxidative damage to bio-membrane,enzyme,amino acid and protein etc,and lead to diseases.Current research discovered that there is a certain correlation between viral infection with the generation of free radicals.In this article,the interaction between the production of free radicals and viral infection were reviewed.

关 键 词：自由基 病毒感染 氧化应激 

分 类 号：S852.65[农业科学—基础兽医学]