T细胞免疫重建的临床策略  

Clinical Strategies for T Cell Immune Reconstitution

作　　者：尹帆[1] 李江[1] 李玉谷[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642

出　　处：《动物医学进展》2011年第6期171-174,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(30871834);高校博士点专项科研基金项目(20094404110015)

摘　　要：T细胞不足或缺乏,与胸腺萎缩相关,往往发生在感染、自身免疫病、化疗/放疗、免疫系统老化等过程中。逆转胸腺萎缩,重建T细胞免疫,目前已经或有望用于临床治疗的有IL-7、IL-15、IL-12、KGF、GH、Ghrelin、Flt3L、性激素抑制剂、T细胞前体等,论文就这些制剂在T细胞免疫重建中的作用进行综述。T cell deficiencies have been associated with thymic atrophy and often occur in infections,autoimmune diseases,chemo/radiotherapy as well as aging of the immune system.Currently,several strategies for reversal of thymic atrophy and T cell reconstitution are being tested in the clinic,such as,using interleukin-7,interleukin-15,interleukin-12,keratinocyte growth factor,growth hormone,ghrelin,Flt3L,sex hormone inhibitors and T-cell precursors etc.In this paper,the effects of these factors on T cell immune reconstitution were reviewed.

关 键 词：T细胞 IL-7 KGF GH 性激素 

分 类 号：S852.4[农业科学—基础兽医学]