多肽“困难序列”的合成研究进展  

Advances of Synthesis for Difficult-sequences in Peptide

作　　者：姜和[1,2] 吴洋[1,2] 陆荣健 

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400054 [2]重庆前沿生物技术有限公司,重庆400041

出　　处：《重庆理工大学学报（自然科学）》2011年第5期23-30,共8页Journal of Chongqing University of Technology：Natural Science

基　　金："十一五"科技重大专项资助项目(2009ZX09401-004)

摘　　要：一般而言，某些肽链长度大约在6～16个残基内，几乎每步缩合都很难完成，这一区间的肽段被称为“困难序列”。肽链间或内部的聚集生成了困难序列，困难序列的存在导致缩合很难完全。针对该问题，综述了困难序列生成的原因以及有效提高困难序列缩合效率的方法，并对这些方法进行了比较。Generally speaking, some peptide sequences are very difficult to coupling reaction at every step, are inter-chain aggregation leads to the difficult sequences. of the difficult sequences from the reasoning of difficult in the length range of 6 - 16 residues, which called as the difficult sequences. The intra-or This paper reviews the recent progress in field sequences formation to the method of improving the coupling efficiency of difficult sequences. These methods have broad application in both solidphase and liquid-phase peptide synthesis of difficult sequences

关 键 词：困难序列 困难肽 缩合效率 分子聚集 Β-折叠 

分 类 号：Q516[生物学—生物化学]