2型糖尿病肾病患者血清抵抗素水平的变化  

Change of resistin in patients with type 2 diabetic nephropathy.

作　　者：陈小盼[1] 朱洪[2] 宋钦华[1] 郑海龙[1] 孙胜花[1] 李国铨[1] 

机构地区：[1]海南医学院附属医院内分泌科,海南海口570102 [2]海南医学院附属医院检验科,海南海口570102

出　　处：《海南医学》2011年第11期12-13,共2页Hainan Medical Journal

基　　金：海南省自然科学基金项目(编号:808237)

摘　　要：目的观察2型糖尿病肾病患者血清抵抗素水平的变化及其临床意义。方法临床选择研究对象119例,分为单纯2型糖尿病组(35例)、2型糖尿病肾病组(54例)和正常对照组(30例)。所有研究对象均测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、24h尿白蛋白定量(24hUA)和抵抗素水平。结果单纯2型糖尿病组、2型糖尿病肾病组分别与正常对照组比较,FPG、HbA1c和抵抗素水平均差异有统计学意义(P<0.05),2型糖尿病肾病组24hUA明显高于正常对照组(P<0.05),而单纯2型糖尿病组与正常对照组差异无统计学意义(P>0.05);2型糖尿病肾病组与单纯2型糖尿病组对比,两组之间的FPG、HbA1c差异无统计学意义(P>0.05),但2型糖尿病肾病组24hUA和抵抗素水平明显高于单纯2型糖尿病组(P<0.05)。结论抵抗素可能在2型糖尿病肾病的发病中起着重要的作用,可以作为临床2型糖尿病肾病诊断的重要评判指标。Objective To investigate the change of resistin in patients with type 2 diabetic nephropathy.Methods 119 subjects were divided into three groups：type 2 diabetic mellitus without nephropathy group（T2DM group,n=35）,type 2 diabetic nephropathy group（DN group,n=54） and control group（n=30）.Fasting blood glucose（FPG）,glycosylated hemoglobinm（HbA1c）,quantitative level of 24-hour urinary albumin（24 h UA） and resistin were measured in all subjects.Results The level of FPG,HbA1c,resistin in both the T2DM group and the DN group were different with those in the control group（P0.05）,and quantitative level of 24 h UA in the DN group was significantly higher than that in the control group（P0.05）.There was no different on 24 h UA between the T2DM group and the control group.Compared to those in the T2DM group,FPG and HbA1c were not different and quantitative level of 24h UA and resistin was significantly higher in the DN group.Conclusion Resistin may play an important role in the development of type 2 diabetic nephropathy,and it can be used to diagnose diabetic nephropathy.

关 键 词：糖尿病 抵抗素 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]