企业机关体检人群中丙氨酸氨基转移酶异常的相关因素分析  

Analysis on causes and related factors for elevation of serum level of ALT in staffs of enterprises

作　　者：胡安梅[1] 王志凯[1] 李尔曼[1] 陈远惠[1] 魏书侠[1] 

机构地区：[1]中国石油中心医院保健中心,河北廊坊065000

出　　处：《临床和实验医学杂志》2011年第12期920-922,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨企业机关健康体检人群中丙氨酸氨基转移酶(ALT)升高率与其升高的相关因素,为正确分析引起ALT升高的原因提供相关依据。方法以参与体检的8 734名体检人群为研究对象,收集身高、体质量、血压、ALT、空腹血糖、高密度脂蛋白、低密度脂蛋白、总胆固醇、三酰甘油、血清乙肝表面抗原、脂肪肝及胆石症等相关资料进行分析。结果在全部体检人群中,ALT升高率为10.11%,男性ALT升高率为12.3%,女性ALT升高率为6.2%,男性明显高于女性(P<0.001);ALT升高组的年龄均数小于ALT正常组(P<0.001);在ALT升高的受检者中,脂肪肝、高脂血症、肥胖、糖尿病、胆囊结石、饮酒及乙肝等患病率均高于ALT正常组受检者(P<0.05)。结论脂肪肝、糖脂代谢紊乱及乙肝是体检人员ALT升高的主要原因;男性和低龄也是体检者ALT升高的危险因素。Objective To study the prevalence and related factors for elevated serum level of alanine aminotransferase（ALT） in staffs of enterprises and to provide scientific basis for further exploration of its causes and improvement of health care in enterprises.Methods Persons received medical examination for health in Center of Physical Examination were screened in this study.The data of their height,body weight,blood pressure,serum level of ALT,fasting plasma glucose level,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,total cholesterol,triglyceride,hepatitis B surface antigen（HBsAg）,fatty liver and cholelithiasis were collected and analyzed.Results A total of 8734 persons were included in this study.The total incidence of elevated serum level of ALT was 10.11% including 12.3% of males and 6.2% of females,and the difference between men and women was statistically significant（P0.001）.The mean age of persons in ALT elevated group was obviously lower than those with normal ALT group（P0.001）.The incidence rates of fatty liver,hyperlipidemia,obesity,diabetes,gallstones,alcoholic drinking and positive hepatitis B surface antigen in ALT elevated group were significantly higher than those in persons of normal ALT group（P0.05）.Conclusion Fatty liver,disorder in carbohydrate and lipid metabolism and hepatitis B were main causes for the occurrence of elevated serum level of ALT.Both males and young persons were high risk population for elevated serum level of ALT in this study.

关 键 词：体检人群 丙氨酸氨基转移酶升高 相关因素 

分 类 号：R446.11[医药卫生—诊断学]