低分子肝素钙对家兔急性油酸型肺损伤的影响  

Protective effect of low molecular weight heparin calcium on oleic acid-induced acute lung injury in rabbits

作　　者：马静波[1] 沙婷[1] 桑黎黎[2] 董薇[2] 

机构地区：[1]徐州医学院,2008级4班临床专业江苏221004 [2]徐州医学院机能学实验中心

出　　处：《齐齐哈尔医学院学报》2011年第8期1202-1203,共2页Journal of Qiqihar Medical University

摘　　要：目的研究低分子肝素钙对家兔急性油酸型肺损伤的影响。方法耳缘静脉注射高纯度油酸制备ALI家兔模型。将24只家兔随机分为两组,油酸组、低分子肝素钙治疗组。测定动脉血气变化、凝血功能和肺系数,观察肺组织病理变化。结果低分子肝素钙治疗组PCO2(45.5±4.183)、PO2(76.5±3.391),PT(12.03±0.624)、APTT(23.33±1.467)、TT(18.45±1.559),肺系数(6.34±0.356),与油酸组比较,有统计学意义(P<0.05);低分子肝素钙治疗组肺系数低于油酸组;光镜下,低分子肝素钙治疗组肺组织充血、水肿及炎性细胞浸润情况较油酸组轻。结论 低分子肝素钙对急性肺损伤有一定治疗作用。Objective To investigate the potential beneficial effects of low molecular weight hepa- rin calcium（LMWHC）on oleic acid--induced acute lung injury in rabbits. Methods Twenty--four rabbits were randomly divided into two groups （n= 12） ： oleic acid control group and LMWHC group. ALI rabbit models were made by oleic acid. After one hour, arterial blood was collected to measure the levels of coagulating factors and test the oxygen levels. After all the rabbits were sacrificed, lung was observed, checked for Lung index and made for organization slice. Results LMWHC cured group, PCO2 （45.50±4.183）, PO2 （76. 0±3. 391）, PT（12. 03±0. 624）, APTT（23. 33± 1. 467）, TT（18. 45 ± 1. 559）, Lung index5.34±0. 356, the results from the study showed marked discrepancy compared with control （P 〈 0.05）. The Lung index of the LMWHC group was lower than the oleic acid control group. Under the microscope, the lungs of rabbits in oleic acid control group had spotty hemorrhage and more inflammatory granulocytes, after treated with LMWHC, the histopathological changes induced by oleic acid were relieved. Conclusions LMWHC has some potential beneficial effects on oleic acid injecting injury.

关 键 词：低分子肝素钙 急性肺损伤 凝血因子 炎症反应 

分 类 号：R285.5[医药卫生—中药学]