新生儿硬肿症患儿尿视黄醇结合蛋白改变的临床意义  

Clinical values for changes of urine retinol binding protein in patients with neonatal scleredema.

作　　者：苏赞彩[1] 许逢明[1] 周毅虹[1] 陈铭珍[1] 

机构地区：[1]广东医学院附属医院儿科,湛江524001

出　　处：《中国优生与遗传杂志》1999年第5期81-81,共1页Chinese Journal of Birth Health & Heredity

摘　　要：为了解新生儿患儿肾小管功能变化，应用ＥＬＩＳＡ法检测３６ 例新生儿硬肿症患儿尿视黄醇结合蛋白（ＲＢＰ）。结果显示硬肿症患儿尿ＲＢＰ明显高于对照组（ Ｐ＜ ０．０１） ，中、重度硬肿症组均高于对照组（ Ｐ＜０ ．０５ ，Ｐ＜ ０．０１） 。而轻度硬肿症组与对照组的差异无显著性（ Ｐ＞ ０ ．０５） ，提示中、重度新生儿硬肿症患儿存在有肾小管功能的损害。Objective:To explore the renal tubular changes in sick infants with neonatal scleredema(NS).Methods:All of the 36 cases of scleredema patients were divided into three groups:mild,moderate and profound.With the technique of ELISA,the urine retinol binding protein(RBP) concentrations were determined in these patients.Results:The urine RBP concentrations in these patients and in the latter two groups:moderate and profound,showed a significantly higher rise (P<0.01,P<0.05,P<0.01),respectively,than that of the control group while the concentrations in mild group showed no marked difference (P>0.05)compared with the control group.Conclusions:It′s suggested that patients attacked by moderate and profound neonatal scleredema were usually accompanied by the compromise of renal tubular function.

关 键 词：新生儿硬肿症 视黄醇结合蛋白 肾小管损伤 

分 类 号：R692.6[医药卫生—泌尿科学] R722.160.6[医药卫生—外科学]