用钙阻滞剂抑制心脏中的螺旋波和时空混沌  

Suppressing Spiral Wave and Spatiotemporal Chaos in Cardiac Tissue by Using Calcium Channel Blockade

作　　者：肖向华[1] 唐国宁[1] 

机构地区：[1]广西师范大学物理科学与技术学院,广西桂林541004

出　　处：《复杂系统与复杂性科学》2011年第2期58-63,共6页Complex Systems and Complexity Science

基　　金：国家自然科学基金(10765002)

摘　　要：采用钙离子通道阻滞剂抑制心脏组织中的螺旋波和时空混沌。针对使用钙离子通道阻滞剂单纯减少钙离子流的最大电导率不能达到控制目的,提出使用钙离子通道阻滞剂调制钙离子流的最大电导率,使之按行波方式变化。在钙电导率按行波方式变化下,观察到时空混沌转变成螺旋波的现象,对控制机制作了简要讨论。研究结果表明:在适当选取控制参数下,该方法能在短时间内抑制螺旋波和时空混沌,使系统回到静息态。The suppression of spiral waves and spatiotemporal chaos in cardiac via calcium channel blockade is considered.It is generally accepted that spiral waves and spatiotemporal chaos can＇t be suppressed by calcium channel-blocking drug when the maximum conductivity of calcium current is monotonously reduced by the drug.So we propose a control strategy which applies blockade to modulate the maximum conductivity of calcium current and lead to change of the conductivity in the form of traveling-wave.The phenomenon that the modulated calcium conductivity transforms spatiotemporal chaos into spiral wave is observed.The control mechanism is briefly discussed.The numerical results show that the control method can quickly eliminate the spiral waves and spatiotemporal chaos in cardiac tissue when the related parameters are properly chosen.The system returns to the rest state after transient drug controls.

关 键 词：螺旋波 时空混沌 钙电导 行波调制 

分 类 号：O415[理学—理论物理] Q612[理学—物理]