慢性肺源性心脏病患者红细胞免疫粘附功能的研究  

Study on the erythrocyte adhesive function in patients with chronic pulmonary heart disease

作　　者：林彦[1] 陈学魁[2] 刘长庭[1] 张进川[1] 

机构地区：[1]解放军总医院南楼一科,北京100853 [2]白求恩医科大学二院呼吸内科,长春130041

出　　处：《军医进修学院学报》1999年第4期286-287,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：通过对肺心病患者红细胞免疫粘附功能进行研究，进一步探讨慢性肺源性心脏病免疫调节机制。方法：检测２７ 例肺心病患者外周血红细胞免疫复合物花环率（ＲＩＣＲ）及红细胞膜表面Ｃ３ｂ 受体花环率（ＲＣＲ），其中急发期患者２１ 例，缓解期患者６ 例，并利用流式细胞术测定红细胞膜ＣＤ５８ 表达。结果：肺心病组ＲＣＲ在急发期及缓解期均低于对照组（Ｐ＜ ０．００１，Ｐ＜ ０．０００１），急发期较缓解期也有减低（Ｐ＜ ０．０５）。急发期ＲＩＣＲ明显低于对照组，也低于缓解期水平（Ｐ＜ ０．０５）。肺心病组外周血红细胞膜ＣＤ５８ 表达增高（Ｐ＜ ０．０５）。结论：我们认为肺心病患者红细胞免疫调节功能失调，如能改善其免疫功能，可能减少复发。Objective:The erythrocyte adhesive function in 27 patients with chronic pulmonary heart disease (CPHD) was observed. Methods:In total 27 CHPD patients, 21 were in acute attack stage and 6 in remission stage. The RICR, RCR and CD 58 were tested by flowcytometer. Results:(1) RCR level in CPHD was worse than those in the control. In acute attack cases, RCR level was the lowest. (2) RICR level of acute attack cases showed decreased. (3) CD 58 on membrane of erythrocyte expressed stronger in CPHD, neither did it improve in remission cases nor did it return to normal level. Conclusion:The erythrocyte adhesive function in patients with CPHD seems to be markedly disturbed. In order to prevent relapse, we should improve the immune ability of erythrocyte by treating the patients with CPHD.

关 键 词：肺心病 红细胞免疫 CD58 粘附功能 

分 类 号：R541.503[医药卫生—心血管疾病]