血浆脑钠肽及脂肪酸结合蛋白水平与慢性收缩性心力衰竭关系的探讨  

Investigation of the relationships among plasma B type natriuretic peptide,fatty acid binding protein and chronic congestive heart failure

作　　者：曹磊[1] 

机构地区：[1]河北省保定市第二医院特诊二科,071051

出　　处：《疑难病杂志》2011年第6期408-410,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的测定慢性收缩性心力衰竭(CHF)患者的血浆脑钠肽(BNP)及血清脂肪酸结合蛋白(FABP)水平,探讨血浆BNP及血清FABP对CHF诊断及心功能评估的价值。方法选择住院CHF患者60例,其中NYHAⅠ级12例,Ⅱ级18例,Ⅲ级20例,Ⅳ级10例;原发疾病:冠心病30例,瓣膜性心脏病9例,扩张型心肌病10例,高血压性心脏病11例。另纳入20例健康体检者为健康对照组,分别测定BNP及FABP浓度,评价心功能。结果 CHF组血浆BNP及血清FABP水平显著高于健康对照组(P<0.01);且随着心力衰竭程度的加重,CHF患者的BNP及FABP水平逐渐增高(NYHAⅣ级>NYHAⅢ级>NYHAⅡ级,P均<0.01);LVEF≤40%患者显著高于LVEF>40%患者(P<0.01);而不同病因CHF患者间2项指标差异无统计学意义(P>0.05)。BNP与FABP呈正相关(r=0.801,P<0.01),两者与LVEF呈负相关(r=-0.718,r=-0.881,P<0.01)。结论血浆BNP及血清FABP测定对CHF的诊断和心功能的分级及预后判断都有重要的临床价值。Objective To determine the plasma B type natriuretic peptide（BNP）and fatty acid binding protein（FABP） levels in patients with chronic heart failure（CHF）,and to investigate the value of plasma BNP and FABP in diagnose of patients with chronic heart failure and in assessment of cardiac function.Methods There were 60 cases of CHF,according to NYHA classification,12 cases were in degree ofⅠ,18 cases wereⅡ,20 wereⅢ,10 cases inⅣ.Primary disease：30 cases with CHD,9 cases with valvular heart disease,10 cases with dilated cardiomyopathy, 11 cases with hypertensive heart disease.The plasma BNP and.FABP concentration in these 60 patients with chronic heart failure and 20 controls were determined,cardiac function assessment was conducted.Results Level of plasma BNP and FABP in CHF group were significantly higher than that of the control group（P0.01）;and with the increase of degree of heart failure,plasma BNP and FABP levels gradually increased（NYHAⅣNYHAⅢNYHAⅡ,P0.01）,meanwhile patients with LVEF≤40%significantly higher than patients with LVEF40% （P0.01）.BNP was positively correlated with FABP（r=0.801,P0.01）,BNP and FABP were negatively correlated with LVEF（r=-0.718,r=-0.881,P0.01）.Conclusion The assay of plasma BNP and FABP concentration are with important value in diagnose of CHF,and in the classification of cardiac function and prognosis.

关 键 词：脑钠肽 脂肪酸结合蛋白 心力衰竭 收缩性 慢性 

分 类 号：R541.6[医药卫生—心血管疾病]